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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for ANPR-A receptor complex
Gene ontology ID
GO:1990620
Definition
A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure
Comment
An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
Synonyms
1. NPR1 receptor complex
References
1. GOC: ame
2. PMID 15117952
3. IntAct: EBI-10093340
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