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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for PCSK9-LDLR complex
Gene ontology ID
GO:1990666
Definition
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway
Synonyms
1. PCSK9.LDLR complex
2. PCSK9/LDL-R complex
3. PCSK9:EGF-A complex
4. PCSK9:low-density lipoprotein receptor complex
References
1. GOC: BHF
2. GOC: nc
3. PMID 18250299
4. PMID 24440079
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is a part of the parent element
is related to the parent element
derives from the parent element
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