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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for amyloid-beta complex
Gene ontology ID
GO:0106003
Definition
Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease
Comment
An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay).
Synonyms
1. Abeta complex
2. Abeta-derived diffusible ligand complex
3. ADDL complex
4. amyloid beta complex
5. amyloid beta dimer
6. amyloid beta heterodimer
7. amyloid beta heterooligomer
8. amyloid beta heterotrimer
9. amyloid beta homodimer
10. amyloid beta homooligomer
11. amyloid beta homotrimer
12. amyloid beta oligomer
13. amyloid beta trimer
14. amyloid-beta protein 40 complex
15. amyloid-beta protein 40/42 complex
16. amyloid-beta protein 42 complex
17. beta amyloid complex
18. beta-amyloid complex
19. betaA complex
20. heterodimer of amyloid beta protein
21. heterooligomer of amyloid beta protein
22. heterotrimer of amyloid beta protein
23. homodimer of amyloid beta protein
24. homooligomer of amyloid beta protein
25. homotrimer of amyloid beta protein
References
1. GOC: bhm
2. PMID 18568035
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