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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for Lsm1-7-Pat1 complex
Gene ontology ID
GO:1990726
Definition
A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway
References
1. GOC: bhm
2. GOC: krc
3. PMID 19121818
4. PMID 23620288
5. PMID 24139796
6. PMID 27627834
7. PMID 28768202
8. IntAct: EBI-16419327
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