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Gene ontology
Version 2014-12-22
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Details for nodal receptor complex
Gene ontology ID
GO:0038104
Definition
A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell
Comment
Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex.
Synonyms
1. ActRIIB.ALK4.EGF-CFC complex
References
1. GOC: bf
2. GOC: signaling
3. PMID 11024047
4. PMID 15062104
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is a part of the parent element
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derives from the parent element
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