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Gene ontology
Version 2014-12-22
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Details for THO complex
THO complex
Gene ontology ID
GO:0000347
Definition
The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits
References
1. GOC: krc
2. PMID 11060033
3. PMID 11979277
4. PMID 16983072
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