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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for calprotectin complex
Gene ontology ID
GO:1990660
Definition
A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways
Comment
An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
Synonyms
1. calprotectin heterodimer
References
1. GOC: bhm
2. PMID 25417112
3. IntAct: EBI-10098135
4. IntAct: EBI-10098681
5. IntAct: EBI-10098713
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