Any feedback?
Please rate this page
(ontology.php)
(0/150)

BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
use AND (NOT) or OR
use AND (NOT) or OR
restrict to BRENDA links:
103 different search results found


Details for CLOCK-BMAL transcription complex
Gene ontology ID
GO:1990513
Definition
Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms
Comment
An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
Synonyms
1. CLOCK/BMAL complex
References
1. GOC: bhm
2. PMID 23229515
3. IntAct: EBI-9696362
4. IntAct: EBI-9696901
5. IntAct: EBI-9696921
6. IntAct: EBI-9696951
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
Tree view
Gene ontology