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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for podosome
podosome
Gene ontology ID
GO:0002102
GO:0002102 is linked to 2 enzymes:
Definition
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm
Comment
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
References
1. PMID 12837608
2. PMID 15890982
3. Wikipedia: Podosome
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