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Gene ontology
Version 2014-12-22
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Details for nuclear SCF ubiquitin ligase complex
Gene ontology ID
GO:0043224
Definition
A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)
Synonyms
1. nuclear cullin complex
2. nuclear SCF complex
3. nuclear Skp1/Cul1/F-box protein complex
References
1. PMID 15571813
2. PMID 15688063
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