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Gene ontology
Version 2014-12-22
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Details for neurofibrillary tangle
neurofibrillary tangleneurofibrillary tangle
Gene ontology ID
GO:0097418
Definition
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star
Comment
Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Synonyms
1. flame-shaped neurofibrillary tangle
2. star-shaped neurofibrillary tangle
References
1. NIF Subcellular: nlx subcell 20090201
2. NIF Subcellular: nlx subcell 20090202
3. NIF Subcellular: sao2409833926
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