Gene ontology ID
GO:1990513
Definition
Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms
Comment
An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
Synonyms
1. CLOCK/BMAL complex
References
1. GOC: bhm
2. PMID 232295153. IntAct: EBI-9696362
4. IntAct: EBI-9696901
5. IntAct: EBI-9696921
6. IntAct: EBI-9696951
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA