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Gene ontology
Version 2014-12-22
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Details for interleukin-35 complex
Gene ontology ID
GO:0070745
Definition
A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space
Comment
Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
Synonyms
1. EBI3
2. IL-35 complex
3. IL12A
4. p35
References
1. GOC: add
2. PMID 19161428
3. PMID 19161429
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