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Gene ontology
Version 2014-12-22
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Details for N-acylsphingosine amidohydrolase activity
3.5.1.23
Gene ontology ID
GO:0017040
Definition
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine
Synonyms
1. acylsphingosine deacylase activity
2. glycosphingolipid ceramide deacylase
3. N-acylsphingosine amidohydrolase activity
References
1. EC 3.5.1.23
2. MetaCyc CERAMIDASE-RXN
3. Reactome: R-HSA-1606583 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)"
4. Reactome: R-HSA-1606602 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)"
5. Reactome: R-HSA-428205 "ceramide + H2O => stearate + sphingosine [Golgi]"
6. Reactome: R-HSA-428231 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]"
7. RHEA: 20856
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
hydrolase activity is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is a
N-acylsphingosine amidohydrolase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity is a
3-(N-formyl)-formiminopyruvate hydrolase activity is a
3-formiminopyruvate hydrolase activity is a
aminohydroquinone monooxygenase activity is a
gamma-aminovinylacetate deaminase activity is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is a
(3,5-dichlorophenylurea)acetate amidohydrolase activity is a
(S)-N-acetyl-1-phenylethylamine hydrolase activity is a
2-(acetamidomethylene)succinate hydrolase activity is a
2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity is a
2-oxoglutaramate amidase activity is a
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity is a
4-methyleneglutaminase activity is a
5-aminopentanamidase activity is a
6-aminohexanoate-dimer hydrolase activity is a
aculeacin-A deacylase activity is a
acyl-lysine deacylase activity is a
acylagmatine amidase activity is a
adenosine 5'-monophosphoramidase activity is a
adenosylcobinamide hydrolase activity is a
alkylamidase activity is a
allophanate hydrolase activity is a
amidase activity is a
aminoacylase activity is a
anandamide amidohydrolase activity is a
aryl-acylamidase activity is a
arylalkyl acylamidase activity is a
arylformamidase activity is a
asparaginase activity is a
aspartoacylase activity is a
beta-ureidopropionase activity is a
biotinidase activity is a
biuret amidohydrolase activity is a
carnitinamidase activity is a
ceramidase activity is a
chenodeoxycholoyltaurine hydrolase activity is a
chitin disaccharide deacetylase activity is a
choloylglycine hydrolase activity is a
cis-aconitamide amidase activity is a
citrullinase activity is a
D-benzoylarginine-4-nitroanilide amidase activity is a
D-glutaminase activity is a
deaminated glutathione amidase activity is a
diacetylchitobiose deacetylase activity is a
didemethylisoproturon amidohydrolase activity is a
fatty acid amide hydrolase activity is a
formamidase activity is a
formylaminopyrimidine deformylase activity is a
formylaspartate deformylase activity is a
formylmethionine deformylase activity is a
formyltetrahydrofolate deformylase activity is a
gamma-glutamyl-gamma-aminobutyrate hydrolase activity is a
gamma-N-formylaminovinylacetate hydrolase activity is a
glutamin-(asparagin-)ase activity is a
glutaminase activity is a
glutaryl-7-aminocephalosporanic-acid acylase activity is a
glutathionylspermidine amidase activity is a
glycosphingolipid deacylase activity is a
hippurate hydrolase activity is a
indoleacetamide hydrolase activity is a
iprodione amidohydrolase activity is a
isonicotinic acid hydrazide hydrolase activity is a
linuron hydrolase activity is a
lipoamidase activity is a
long-chain fatty-acyl-glutamate deacylase activity is a
mandelamide amidase activity is a
mimosinase activity is a
N(alpha)-benzyloxycarbonylleucine hydrolase activity is a
N,N-dimethylformamidase activity is a
N-(long-chain-acyl)ethanolamine deacylase activity is a
N-acetylcitrulline deacetylase activity is a
N-acetylmuramoyl-L-alanine amidase activity is a
N-acyl-D-amino-acid deacylase activity is a
N-acyl-D-aspartate deacylase activity is a
N-acyl-D-glutamate deacylase activity is a
N-acylsphingosine amidohydrolase activity is a
N-benzyloxycarbonylglycine hydrolase activity is a
N-carbamoyl-D-amino acid hydrolase activity is a
N-carbamoyl-L-amino-acid hydrolase activity is a
N-carbamoylputrescine amidase activity is a
N-carbamoylsarcosine amidase activity is a
N-cyclohexylformamide amidohydrolase activity is a
N-feruloylglycine deacylase activity is a
N-formylglutamate deformylase activity is a
N-formylmethionylaminoacyl-tRNA deformylase activity is a
N-glutamylanilide hydrolase activity is a
N-isopropylacetanilide amidohydrolase activity is a
N-malonylurea hydrolase activity is a
N-methyl-2-oxoglutaramate hydrolase activity is a
N-substituted formamide deformylase activity is a
N2-acetyl-L-lysine deacetylase activity is a
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity is a
N4-acetylcytidine amidohydrolase activity is a
nicotinamidase activity is a
nicotinamide-nucleotide amidase activity is a
oleamide hydrolase activity is a
omega-amidase activity is a
pantetheine hydrolase activity is a
pantothenase activity is a
para-aminobenzoyl-glutamate hydrolase activity is a
penicillin amidase activity is a
pentanamidase activity is a
peptide deformylase activity is a
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity is a
peptidyl-glutaminase activity is a
phthalyl amidase activity is a
protein-glutamine glutaminase activity is a
protein-N-terminal asparagine amidohydrolase activity is a
protein-N-terminal glutamine amidohydrolase activity is a
succinyl-diaminopimelate desuccinylase activity is a
succinylglutamate desuccinylase activity is a
theanine hydrolase activity is a
tryptophanamidase activity is a
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity is a
urease activity is a
ureidosuccinase activity is a
urethanase activity is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles is a
hydroxydechloroatrazine ethylaminohydrolase activity is a
IAA-amino acid conjugate hydrolase activity is a
jasmonic acid hydrolase is a
jasmonyl-Ile conjugate hydrolase activity is a
N-acetyl-anhydromuramoyl-L-alanine amidase activity is a
N-isopropylammelide isopropylaminohydrolase activity is a
riboflavinase activity is a
thiaminase activity is a
trans-ACOHDA hydrolase activity is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a