Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate
1. EC 2.7.10.12. GOC: mah
3. MetaCyc 2.7.10.1-RXN4. Reactome: R-HSA-166544 "TrkA receptor autophosphorylates"
5. Reactome: R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated"
6. Reactome: R-HSA-167683 "TrkA phosphorylates PLCG1"
7. Reactome: R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor"
8. Reactome: R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR"
9. Reactome: R-HSA-198295 "TRKA phosphorylates IRS"
10. Reactome: R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA"
11. Reactome: R-HSA-74711 "Phosphorylation of IRS"
12. Reactome: R-HSA-74715 "Autophosphorylation of insulin receptor"
13. Reactome: R-HSA-74742 "Phosphorylation of SHC1"
14. Reactome: R-HSA-8852552 "MST1R autophosphorylates"
15. Reactome: R-HSA-8853792 "RET tyrosine phosphorylation"
16. Reactome: R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor"
17. Reactome: R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation"
18. Reactome: R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction"
19. Reactome: R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated"
20. Reactome: R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated"
21. Reactome: R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated"
22. Reactome: R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4"
23. Reactome: R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction"
24. Reactome: R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated"
25. Reactome: R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated"
26. Reactome: R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated"
27. Reactome: R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
28. Reactome: R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1"
29. Reactome: R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1"
30. Reactome: R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5"
31. Reactome: R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2"
32. Reactome: R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5"
33. Reactome: R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2"
34. Reactome: R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA"
35. Reactome: R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1"
36. Reactome: R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1"
37. Reactome: R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
38. Reactome: R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3"
39. Reactome: R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1"
40. Reactome: R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
41. Reactome: R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated"
42. Reactome: R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3"
43. Reactome: R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3"
44. Reactome: R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3"
45. Reactome: R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
46. Reactome: R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3"