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Gene ontology
Version 2014-12-22
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Details for transmembrane receptor protein tyrosine kinase activity
2.7.10.1
Gene ontology ID
GO:0004714
Definition
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate
Synonyms
1. anaplastic lymphoma kinase activity
2. ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity
3. ATP:protein-tyrosine O-phosphotransferase activity
4. Drosophila Eph kinase activity
5. ephrin-B3 receptor tyrosine kinase activity
6. insulin receptor protein-tyrosine kinase activity
7. neurite outgrowth regulating kinase activity
8. neurotrophin TRK receptor activity
9. neurotrophin TRKA receptor activity
10. neurotrophin TRKB receptor activity
11. neurotrophin TRKC receptor activity
12. novel oncogene with kinase-domain activity
13. receptor protein tyrosine kinase activity
14. receptor protein-tyrosine kinase activity
15. sevenless receptor activity
References
1. EC 2.7.10.1
2. GOC: mah
3. MetaCyc 2.7.10.1-RXN
4. Reactome: R-HSA-166544 "TrkA receptor autophosphorylates"
5. Reactome: R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated"
6. Reactome: R-HSA-167683 "TrkA phosphorylates PLCG1"
7. Reactome: R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor"
8. Reactome: R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR"
9. Reactome: R-HSA-198295 "TRKA phosphorylates IRS"
10. Reactome: R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA"
11. Reactome: R-HSA-74711 "Phosphorylation of IRS"
12. Reactome: R-HSA-74715 "Autophosphorylation of insulin receptor"
13. Reactome: R-HSA-74742 "Phosphorylation of SHC1"
14. Reactome: R-HSA-8852552 "MST1R autophosphorylates"
15. Reactome: R-HSA-8853792 "RET tyrosine phosphorylation"
16. Reactome: R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor"
17. Reactome: R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation"
18. Reactome: R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction"
19. Reactome: R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated"
20. Reactome: R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated"
21. Reactome: R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated"
22. Reactome: R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4"
23. Reactome: R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction"
24. Reactome: R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated"
25. Reactome: R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated"
26. Reactome: R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated"
27. Reactome: R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
28. Reactome: R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1"
29. Reactome: R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1"
30. Reactome: R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5"
31. Reactome: R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2"
32. Reactome: R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5"
33. Reactome: R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2"
34. Reactome: R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA"
35. Reactome: R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1"
36. Reactome: R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1"
37. Reactome: R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
38. Reactome: R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3"
39. Reactome: R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1"
40. Reactome: R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
41. Reactome: R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated"
42. Reactome: R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3"
43. Reactome: R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3"
44. Reactome: R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3"
45. Reactome: R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
46. Reactome: R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3"
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// tissue/ enzyme/ localization link to BRENDA
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