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Gene ontology
Version 2014-12-22
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Details for MAP kinase kinase kinase activity
2.7.11.25
Gene ontology ID
GO:0004709
Definition
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases
Synonyms
1. ATP:protein phosphotransferase (MAPKKKK-activated) activity
2. cMos
3. cRaf
4. MAP3K
5. MAPK/ERK kinase kinase activity
6. MAPKKK activity
7. MEK kinase activity
8. MEKK
9. MEKK activity
10. MEKK1
11. MEKK2
12. MEKK3
13. Mil/Raf
14. mitogen-activated protein kinase kinase kinase activity
15. MLK-like mitogen-activated protein triple kinase activity
16. MLTK
17. MLTKa
18. MLTKb
19. REKS
20. STK28
References
1. PMID 9561267
2. EC 2.7.11.25
3. MetaCyc 2.7.11.25-RXN
4. Reactome: R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex"
5. Reactome: R-HSA-2730887 "Autophosphorylation and activation of MEKK1"
6. Reactome: R-HSA-392530 "p-S400-Cot phosphorylates NIK"
7. Reactome: R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7"
8. Reactome: R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6"
9. Reactome: R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1"
10. Reactome: R-HSA-727819 "TAK1 phosphorylates MKK6"
11. Reactome: R-HSA-933530 "Activation of IKK by MEKK1"
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