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Gene ontology
Version 2014-12-22
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Details for calcidiol 1-monooxygenase activity
1.14.15.18
Gene ontology ID
GO:0004498
Definition
Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)
Synonyms
1. 1-hydroxylase-25-hydroxyvitamin D3 activity
2. 25-hydroxy D3-1alpha-hydroxylase activity
3. 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
4. 25-hydroxycholecalciferol 1-hydroxylase activity
5. 25-hydroxycholecalciferol 1-monooxygenase activity
6. 25-hydroxycholecalciferol 1alpha-hydroxylase activity
7. 25-hydroxycholecalciferol-1-hydroxylase activity
8. 25-hydroxyvitamin D-1 alpha hydroxylase activity
9. 25-hydroxyvitamin D3 1alpha-hydroxylase activity
10. 25-OHD-1 alpha-hydroxylase activity
11. calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
12. cytochrome P450 CYP27B
References
1. EC 1.14.15.18
2. RHEA: 20573
3. KEGG REACTION: R03610
4. MetaCyc CALCIDIOL-1-MONOOXYGENASE-RXN
5. Reactome: R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D"
6. Reactome: R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL"
Legend
is an element of the parent element
is a part of the parent element
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// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological quality is a
regulation of hormone levels is a
hormone metabolic process is a
hormone biosynthetic process is a
steroid hormone biosynthetic process is a
calcitriol biosynthetic process from calciol is a
calcidiol 1-monooxygenase activity part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
regulation of biological quality is a
homeostatic process is a
maintenance of location is a
modulation of age-related behavioral decline is a
regulation of anatomical structure size is a
regulation of appetite is a
regulation of blood pressure is a
regulation of body fluid levels is a
regulation of brood size is a
regulation of buoyancy is a
regulation of circulating fibrinogen levels is a
regulation of DNA stability is a
regulation of hormone levels is a
hormone metabolic process is a
(+)-pinoresinol metabolic process is a
(-)-secoisolariciresinol metabolic process is a
(25S)-Delta(4)-dafachronate metabolic process is a
(25S)-Delta(7)-dafachronate metabolic process is a
acetylcholine metabolic process is a
auxin metabolic process is a
brassinosteroid metabolic process is a
cellular hormone metabolic process is a
ethylene metabolic process is a
gibberellin metabolic process is a
glucocorticoid metabolic process is a
hormone biosynthetic process is a
jasmonic acid biosynthetic process is a
pheromone biosynthetic process is a
quercetin biosynthetic process is a
salicylic acid biosynthetic process is a
steroid hormone biosynthetic process is a
androst-4-ene-3,17-dione biosynthetic process is a
calcitriol biosynthetic process from calciol is a
calcidiol 1-monooxygenase activity part of
vitamin D3 25-hydroxylase activity part of
testosterone biosynthetic process is a
vitamin D3 biosynthetic process is a
strigolactone biosynthetic process is a
hormone catabolic process is a
jasmonic acid metabolic process is a
peptide hormone processing is a
pheromone metabolic process is a
quercetin metabolic process is a
salicylic acid metabolic process is a
strigolactone metabolic process is a
thyroid hormone metabolic process is a
vitamin D3 metabolic process is a
hormone transport is a
regulation of membrane lipid distribution is a
regulation of membrane permeability is a
regulation of membrane potential is a
regulation of neurotransmitter levels is a
regulation of nucleosome density is a
regulation of postsynaptic membrane neurotransmitter receptor levels is a
regulation of protein complex stability is a
regulation of protein stability is a
regulation of R8 cell spacing in compound eye is a
regulation of synapse structure or activity is a
regulation of translational fidelity is a
regulation of tube architecture, open tracheal system is a
regulation of vascular permeability is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a