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Gene ontology
Version 2014-12-22
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Details for phosphatidylinositol phospholipase C activity
3.1.4.11
Gene ontology ID
GO:0004435
Definition
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)
Synonyms
1. 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
2. 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
3. 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
4. monophosphatidylinositol phosphodiesterase activity
5. phosphatidylinositol-4,5-bisphosphate hydrolysis
6. phosphoinositidase C activity
7. phosphoinositide phospholipase C activity
8. PI-PLC activity
9. triphosphoinositide phosphodiesterase activity
References
1. EC 3.1.4.11
2. RHEA: 33179
3. KEGG REACTION: R03435
4. MetaCyc 3.1.4.11-RXN
5. Reactome: R-HSA-111879 "PIP2 hydrolysis"
6. Reactome: R-HSA-167686 "Active PLCG1 hydrolyses PIP2"
7. Reactome: R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane"
8. Reactome: R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane"
9. Reactome: R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane"
10. Reactome: R-HSA-202407 "PLC-gamma1 hydrolyses PIP2"
11. Reactome: R-HSA-2730847 "Hydrolysis of PIP2 by PLCG"
12. Reactome: R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2"
13. Reactome: R-HSA-622382 "PIP2 hydrolysis"
14. Reactome: R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
hydrolase activity is a
hydrolase activity, acting on ester bonds is a
lipase activity is a
phospholipase activity is a
phospholipase C activity is a
phosphatidylinositol phospholipase C activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
aspartyl esterase activity is a
carboxylic ester hydrolase activity is a
DNA-3'-diphospho-5'-guanosine diphosphatase is a
enterochelin esterase activity is a
indole-3-acetyl-beta-1-D-glucose hydrolase activity is a
indole-3-acetyl-beta-4-D-glucose hydrolase activity is a
lipase activity is a
phospholipase activity is a
cardiolipin hydrolase activity is a
N-acylphosphatidylethanolamine-specific phospholipase D activity is a
phospholipase C activity is a
calcium-dependent phospholipase C activity is a
inositol phosphosphingolipid phospholipase activity is a
phosphatidylcholine phospholipase C activity is a
phosphatidylglycerol phospholipase C activity is a
phosphatidylinositol phospholipase C activity is a
phospholipase D activity is a
sphingomyelin phosphodiesterase activity is a
sphingomyelin phosphodiesterase D activity is a
phosphoric ester hydrolase activity is a
sulfuric ester hydrolase activity is a
thiolester hydrolase activity is a
versiconal hemiacetal acetate esterase activity is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a