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Gene ontology
Version 2014-12-22
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Details for hydroxymethylbilane synthase activity
2.5.1.61
Gene ontology ID
GO:0004418
Definition
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)
Comment
Note that this function was formerly EC:4.3.1.8.
Synonyms
1. (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
2. (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
3. HMB-synthase activity
4. porphobilinogen ammonia-lyase (polymerizing)
5. porphobilinogen deaminase activity
6. porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
7. pre-uroporphyrinogen synthase activity
8. uroporphyrinogen I synthase activity
9. uroporphyrinogen I synthetase activity
10. uroporphyrinogen synthase activity
11. uroporphyrinogen synthetase activity
References
1. EC 2.5.1.61
2. RHEA: 13185
3. KEGG REACTION: R00084
4. MetaCyc OHMETHYLBILANESYN-RXN
5. Reactome: R-HSA-189406 "4 PBGs bind to form HMB"
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derives from the parent element
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