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Gene ontology
Version 2014-12-22
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Details for phospholipase C activity
3.1.4.3
Gene ontology ID
GO:0004629
Definition
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate
Synonyms
1. lecithinase C activity
2. lipophosphodiesterase C
3. phosphatidase C
References
1. EC 3.1.4.3
2. GOC: mah
3. MetaCyc PHOSPHOLIPASE-C-RXN
4. Reactome: R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate"
5. Reactome: R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3"
6. Reactome: R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis"
7. Reactome: R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis"
8. Reactome: R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate"
9. Reactome: R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane"
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