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Gene ontology
Version 2014-12-22
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Details for secretory IgA immunoglobulin complex
Gene ontology ID
GO:0071751
Definition
A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component
Comment
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
Synonyms
1. secretory IgA antibody
2. sIgA antibody
3. sIgA1 antibody
References
1. GOC: add
2. ISBN 0781765196
3. PMID 16362985
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