Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, S.; Lin, C.H.; Kwon, D.S.; Walsh, C.T.; Coward, J.K.
    Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli (1997), J. Med. Chem., 40, 3842-3850.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.78 Polyamine-containing phosphopeptides potent and selective inhibitors, which selectively inhibit the synthetase domain over the amidase domain Escherichia coli
6.3.1.8 Hydrogen O-[3-[N-(4-Aminobutyl)amino]propyl][[(gamma-glutamylalanyl)amino]methyl]phosphonate
-
 Escherichia coli
6.3.1.8 additional information design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors Escherichia coli
6.3.1.8 Non-polyamine-containing phosphoamidate
-
 Escherichia coli
6.3.1.8 Polyamine-containing phosphapeptides potent and selective Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.8 gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP Escherichia coli key enzyme that participates in the first of two similar steps of trypanothione biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.78 Escherichia coli
-
 bifunctional enzyme glutathionylspermidine synthetase/amidase
-
6.3.1.8 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.78
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.78 glutathionylspermidine + H2O
-
 Escherichia coli glutathione + spermidine
-
 ?
6.3.1.8 gamma-L-Glu-L-Cys-Gly + spermidine + ATP
-
 Escherichia coli N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + ADP + phosphate
-
 ?
6.3.1.8 gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP key enzyme that participates in the first of two similar steps of trypanothione biosynthesis Escherichia coli ?
-
 ?