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Literature summary extracted from

  • Davis III, A.E.; Alper, C.A.
    Factor I (C3b inactivator) the complement regulatory protease (1984), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 5, 553-558.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.45 C4-binding protein required for hydrolysis of C4b Cavia porcellus
3.4.21.45 C4-binding protein required for hydrolysis of C4b Rattus norvegicus
3.4.21.45 factor H required for hydrolysis of C3b Cavia porcellus
3.4.21.45 factor H required for hydrolysis of C3b Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.45 complement component C3b + H2O Cavia porcellus enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b ?
-
 ?
3.4.21.45 complement component C3b + H2O Rattus norvegicus enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b ?
-
 ?
3.4.21.45 complement component C4b + H2O Cavia porcellus enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b ?
-
 ?
3.4.21.45 complement component C4b + H2O Rattus norvegicus enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.45 Cavia porcellus
-
-
-
3.4.21.45 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.45 side-chain modification glycoprotein Cavia porcellus
3.4.21.45 side-chain modification glycoprotein Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.45 serum
-
 Cavia porcellus
-
3.4.21.45 serum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.45 complement component C3b + H2O
-
 Cavia porcellus complement component C3c + ?
-
 ?
3.4.21.45 complement component C3b + H2O
-
 Rattus norvegicus complement component C3c + ?
-
 ?
3.4.21.45 complement component C3b + H2O enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b Cavia porcellus ?
-
 ?
3.4.21.45 complement component C3b + H2O enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b Rattus norvegicus ?
-
 ?
3.4.21.45 complement component C4b + H2O
-
 Cavia porcellus complement component C4c + C4d
-
 ?
3.4.21.45 complement component C4b + H2O
-
 Rattus norvegicus complement component C4c + C4d
-
 ?
3.4.21.45 complement component C4b + H2O enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b Cavia porcellus ?
-
 ?
3.4.21.45 complement component C4b + H2O enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b Rattus norvegicus ?
-
 ?