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Literature summary extracted from

  • O'Connor, B.; O'Cuinn, G.
    Some properties of synaptosomal membrane-bound pyroglutamate aminopeptidase from guinea-pig brain (1985), Biochem. Soc. Trans., 3, 485-487.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.3 Ca2+ weak inhibition Cavia porcellus
3.4.19.3 Cd2+
-
 Bacillus amyloliquefaciens
3.4.19.3 Cd2+
-
 Cavia porcellus
3.4.19.3 Chelating agents strong Cavia porcellus
3.4.19.3 Cu2+
-
 Bacillus amyloliquefaciens
3.4.19.3 Cu2+
-
 Cavia porcellus
3.4.19.3 Fe3+ weak inhibition Cavia porcellus
3.4.19.3 Mn2+ weak inhibition Cavia porcellus
3.4.19.3 Zn2+
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.19.3 membrane bound to Cavia porcellus 16020
-
3.4.19.3 membrane synaptosomal Cavia porcellus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Bacillus amyloliquefaciens
-
-
-
3.4.19.3 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.3 brain
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 thyroliberin + H2O removes the N-terminal pyroglutamic acid Cavia porcellus pyroglutamate + His-Pro-NH2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.19.3 7.4
-
-
 Cavia porcellus