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Literature summary extracted from

  • Zablocki, K.; Miller, S.P.F.; Garcia-Perez, A.; Burg, M.B.
    Accumulation of glycerophosphocholine (GPC) by renal cells: Osmotic regulation of GPC:choline phosphodiesterase (1991), Proc. Natl. Acad. Sci. USA, 88, 7820-7824.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.2 NaCl cells grown in hyperosmotic medium, 66% inhibition within 6-48 h Canis lupus
3.1.4.2 NaCl cells grown in hyperosmotic medium, 66% inhibition within 6-48 h Oryctolagus cuniculus
3.1.4.2 Urea
-
 Canis lupus
3.1.4.2 Urea
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O Oryctolagus cuniculus cellular phosphatidylcholine catabolic pathway ?
-
 ?
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O Canis lupus cellular phosphatidylcholine catabolic pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.2 Canis lupus
-
-
-
3.1.4.2 Oryctolagus cuniculus
-
 rabbit
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.2 epithelium
-
 Oryctolagus cuniculus
-
3.1.4.2 epithelium
-
 Canis lupus
-
3.1.4.2 MDCK cell
-
 Canis lupus
-
3.1.4.2 PAP-HT25 cell PAP-HT25 renal medullary epithelial cells Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O
-
 Oryctolagus cuniculus sn-glycerol 3-phosphate + choline
-
 ?
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O
-
 Canis lupus sn-glycerol 3-phosphate + choline
-
 ?
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O cellular phosphatidylcholine catabolic pathway Oryctolagus cuniculus ?
-
 ?
3.1.4.2 sn-glycero 3-phosphorylcholine + H2O cellular phosphatidylcholine catabolic pathway Canis lupus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.2 GPC:choline phosphodiesterase
-
 Oryctolagus cuniculus
3.1.4.2 GPC:choline phosphodiesterase
-
 Canis lupus