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Literature summary extracted from

  • Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
    Characterization of the major protein-tyrosine-phosphatases of human placenta (1988), J. Biol. Chem., 263, 6731-6737.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.48 2-mercaptoethanol activation Homo sapiens
3.1.3.48 2-mercaptoethylamine activation Homo sapiens
3.1.3.48 dithiothreitol activation Homo sapiens
3.1.3.48 EDTA activation Homo sapiens
3.1.3.48 glutathione activation Homo sapiens
3.1.3.48 spermidine activation Homo sapiens
3.1.3.48 spermine activation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 diphosphate
-
 Homo sapiens
3.1.3.48 H3VO4
-
 Homo sapiens
3.1.3.48 heparin
-
 Homo sapiens
3.1.3.48 molybdate
-
 Homo sapiens
3.1.3.48 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.48 0.00011
-
 bovine serum albumin calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
3.1.3.48 0.00014
-
 myelin basic protein calculated as mM phosphate released, enzyme subtype 1A, cytoplasmic form Homo sapiens
3.1.3.48 0.00025
-
 myelin basic protein calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
3.1.3.48 0.00026
-
 bovine serum albumin calculated as mM phosphate released, enzyme subtype 1A, cytoplasmic form Homo sapiens
3.1.3.48 0.00028
-
 lysozyme calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
3.1.3.48 0.00045
-
 lysozyme calculated as mM phosphate released , enzyme subtype 1A, cytoplasmic form Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.48 NaF activation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
 phosphatase subtype 1A and 1B
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.48 bovine serum albumin + H2O reduced, carboxamide methylated and succinylated Homo sapiens ? + phosphate
-
 ?
3.1.3.48 lysozyme + H2O reduced, carboxymethylated and maleylated Homo sapiens ? + phosphate
-
 ?
3.1.3.48 myelin basic protein + H2O
-
 Homo sapiens ? + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 5 5.5 substrate 4-nitrophenyl phosphate, subtype 1A Homo sapiens
3.1.3.48 5.5 6 substrate 4-nitrophenyl phosphate, subtype 1B Homo sapiens
3.1.3.48 6.5
-
 substrate lysozyme, enzyme subtypes 1A and 1B Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.48 additional information
-
-
 Homo sapiens