EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.47 | 3-hydroxy-3-methylglutarate | - |
Rattus norvegicus | |
3.1.3.47 | citrate | - |
Rattus norvegicus | |
3.1.3.47 | diphosphate | - |
Rattus norvegicus | |
3.1.3.47 | Maleate | - |
Rattus norvegicus | |
3.1.3.47 | malonate | - |
Rattus norvegicus | |
3.1.3.47 | oxalate | - |
Rattus norvegicus | |
3.1.3.47 | phosphate | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.47 | Mg2+ | activation, inactivation by chelators of divalent cations, metal bound at the catalytic site | Rattus norvegicus | |
3.1.3.47 | Mn2+ | activation, inactivation by chelators of divalent cations, metal bound at the catalytic site | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.3.47 | 310000 | - |
cytosolic isoenzyme IIa, gel chromatography | Rattus norvegicus |
3.1.3.47 | 480000 | - |
cytosolic isoenzyme Ia, gel chromatography | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | Rattus norvegicus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.47 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.3.47 | liver | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.47 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.3.47 | 310 | 315 | no comments on grade of purification, native cytosolic isoenzyme Ia | Rattus norvegicus |
3.1.3.47 | 670 | 710 | no comments on grade of purification, native cytosolic isoenzyme IIa | Rattus norvegicus |
3.1.3.47 | 21480 | - |
purification 4500fold, catalytic subunit of ~35000 Da after ethanol treatment | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.47 | glycogen synthase phosphate + H2O | - |
Rattus norvegicus | glycogen synthase + phosphate | - |
? | |
3.1.3.47 | phosphorylase a phosphate + H2O | - |
Rattus norvegicus | phosphorylase a + phosphate | - |
? | |
3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | - |
? | |
3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | ? | - |
? |