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Literature summary extracted from

  • Hegardt G.; Gil G.; Calvet E.
    Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids (1983), J. Lipid Res., 24, 821-830.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.47 3-hydroxy-3-methylglutarate
-
Rattus norvegicus
3.1.3.47 citrate
-
Rattus norvegicus
3.1.3.47 diphosphate
-
Rattus norvegicus
3.1.3.47 Maleate
-
Rattus norvegicus
3.1.3.47 malonate
-
Rattus norvegicus
3.1.3.47 oxalate
-
Rattus norvegicus
3.1.3.47 phosphate
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.47 Mg2+ activation, inactivation by chelators of divalent cations, metal bound at the catalytic site Rattus norvegicus
3.1.3.47 Mn2+ activation, inactivation by chelators of divalent cations, metal bound at the catalytic site Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.47 310000
-
cytosolic isoenzyme IIa, gel chromatography Rattus norvegicus
3.1.3.47 480000
-
cytosolic isoenzyme Ia, gel chromatography Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.47 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.47 liver Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.47 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.47 310 315 no comments on grade of purification, native cytosolic isoenzyme Ia Rattus norvegicus
3.1.3.47 670 710 no comments on grade of purification, native cytosolic isoenzyme IIa Rattus norvegicus
3.1.3.47 21480
-
purification 4500fold, catalytic subunit of ~35000 Da after ethanol treatment Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.47 glycogen synthase phosphate + H2O
-
Rattus norvegicus glycogen synthase + phosphate
-
?
3.1.3.47 phosphorylase a phosphate + H2O
-
Rattus norvegicus phosphorylase a + phosphate
-
?
3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O
-
Rattus norvegicus [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate
-
?
3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O
-
Rattus norvegicus ?
-
?