Literature summary extracted from

Kembhavi, A.A.; Buttle, D.J.; Rauber, P.; Barrett, A.J.
Clostripain: characterization of the active site (1991), FEBS Lett., 283, 277-280.

General Stability

EC Number	General Stability	Organism
3.4.22.8	Ca2+ stabilizes	Hathewaya histolytica

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.8	Aprotinin	-	Hathewaya histolytica
3.4.22.8	benzamidine	weak	Hathewaya histolytica
3.4.22.8	benzyloxycarbonyl-Phe-Lys-CH2S(CH3)2	irreversible	Hathewaya histolytica
3.4.22.8	diethyldicarbonate	-	Hathewaya histolytica
3.4.22.8	iodoacetamide	-	Hathewaya histolytica
3.4.22.8	iodoacetate	-	Hathewaya histolytica
3.4.22.8	L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane	i.e. compounds E-64	Hathewaya histolytica
3.4.22.8	leupeptin	reversible	Hathewaya histolytica
3.4.22.8	Trypsin inhibitor	Kunitz soybean trypsin inhibitor; limabean trypsin inhibitor	Hathewaya histolytica

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.22.8	Ca2+	half-maximal activity at 0.195 mM	Hathewaya histolytica

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.8	Hathewaya histolytica	-	-	-

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Release 2023.1 (January 2023)