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Literature summary extracted from

  • Fricker, L.D.
    Carboxypeptidase E (1988), Annu. Rev. Physiol., 50, 309-321.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.10
-
 Rattus norvegicus
3.4.17.10
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.10 1,10-phenanthroline
-
 Bos taurus
3.4.17.10 1,10-phenanthroline
-
 Rattus norvegicus
3.4.17.10 Aminopropylmercapto succinic acid
-
 Bos taurus
3.4.17.10 Aminopropylmercapto succinic acid
-
 Rattus norvegicus
3.4.17.10 Guanidinoethylmercaptosuccinic acid
-
 Bos taurus
3.4.17.10 Guanidinoethylmercaptosuccinic acid
-
 Rattus norvegicus
3.4.17.10 p-chloromercuriphenyl sulfonate
-
 Bos taurus
3.4.17.10 p-chloromercuriphenyl sulfonate
-
 Rattus norvegicus
3.4.17.10 sulfhydryl reagents
-
 Bos taurus
3.4.17.10 sulfhydryl reagents
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.10 membrane
-
 Rattus norvegicus 16020
-
3.4.17.10 membrane
-
 Bos taurus 16020
-
3.4.17.10 secretory granule
-
 Rattus norvegicus 30141
-
3.4.17.10 secretory granule chromaffin granules Bos taurus 30141
-
3.4.17.10 soluble
-
 Rattus norvegicus
-
-
3.4.17.10 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.10 Co2+ activates Rattus norvegicus
3.4.17.10 Co2+ activates Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.10 additional information Rattus norvegicus highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids ?
-
 ?
3.4.17.10 additional information Bos taurus highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids ?
-
 ?
3.4.17.10 additional information Rattus norvegicus releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones ?
-
 ?
3.4.17.10 additional information Bos taurus releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.10 Bos taurus
-
-
-
3.4.17.10 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.10 side-chain modification glycoprotein Rattus norvegicus
3.4.17.10 side-chain modification glycoprotein Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.10 adrenal medulla
-
 Rattus norvegicus
-
3.4.17.10 adrenal medulla
-
 Bos taurus
-
3.4.17.10 brain
-
 Rattus norvegicus
-
3.4.17.10 brain
-
 Bos taurus
-
3.4.17.10 heart low activity Rattus norvegicus
-
3.4.17.10 heart low activity Bos taurus
-
3.4.17.10 hypophysis
-
 Rattus norvegicus
-
3.4.17.10 hypophysis
-
 Bos taurus
-
3.4.17.10 additional information 2 forms: soluble and membrane-bound are present in most tissues Rattus norvegicus
-
3.4.17.10 additional information 2 forms: soluble and membrane-bound are present in most tissues Bos taurus
-
3.4.17.10 pancreas low activity Rattus norvegicus
-
3.4.17.10 pancreas low activity Bos taurus
-
3.4.17.10 spleen low activity Rattus norvegicus
-
3.4.17.10 spleen low activity Bos taurus
-
3.4.17.10 testis low activity Rattus norvegicus
-
3.4.17.10 testis low activity Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.10 (Met)enkephalin-Arg + H2O
-
 Rattus norvegicus Tyr-Gly-Gly-Phe-Met + Arg
-
 ?
3.4.17.10 (Met)enkephalin-Arg + H2O
-
 Bos taurus Tyr-Gly-Gly-Phe-Met + Arg
-
 ?
3.4.17.10 (Met)enkephalin-Lys + H2O
-
 Rattus norvegicus Tyr-Gly-Gly-Phe-Met + Lys
-
 ?
3.4.17.10 (Met)enkephalin-Lys + H2O
-
 Bos taurus Tyr-Gly-Gly-Phe-Met + Lys
-
 ?
3.4.17.10 additional information highly specific for C-terminal basic amino acids in decreasing order: Arg, Lys,His, does not cleave other amino acids Rattus norvegicus ?
-
 ?
3.4.17.10 additional information highly specific for C-terminal basic amino acids in decreasing order: Arg, Lys,His, does not cleave other amino acids Bos taurus ?
-
 ?
3.4.17.10 additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin Rattus norvegicus ?
-
 ?
3.4.17.10 additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin Bos taurus ?
-
 ?
3.4.17.10 additional information highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids Rattus norvegicus ?
-
 ?
3.4.17.10 additional information highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids Bos taurus ?
-
 ?
3.4.17.10 additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones Rattus norvegicus ?
-
 ?
3.4.17.10 additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.10 5 6
-
 Rattus norvegicus
3.4.17.10 5 6
-
 Bos taurus