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Literature summary extracted from

  • Soffer, R.L.
    Angiotensin-converting enzyme and the regulation of vasoactive peptides (1976), Annu. Rev. Biochem., 45, 73-94.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 Acetyl-Ala-Ala-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Acetyl-Ala-Ala-Ala-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Ala-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Ala-Ala
-
Sus scrofa
3.4.15.1 Ala-Ala-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Ala-Ala-Ala-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 angiotensin II
-
Cavia porcellus
3.4.15.1 angiotensin II
-
Homo sapiens
3.4.15.1 angiotensin II hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 angiotensin II
-
Sus scrofa
3.4.15.1 Arg-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Arg-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Asp-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 His-Leu hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 His-Leu
-
Sus scrofa
3.4.15.1 Leu-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Lys-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Phe-Arg hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Asn-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Gly-Gly-Trp-Pro-Arg-Pro-Gly-Pro-Glu-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Lys-Trp-Ala-Pro i.e. venom bradykinin-potentiating peptide V-3A, hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Ser-Trp-Pro-Asn-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Pyr-Trp-Pro-Arg-Pro-Thr-Pro-Gln-Ile-Pro-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Ser-Pro hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus
3.4.15.1 Tyr-Ala hydrolysis of hippuryl-His-Leu Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 0.07
-
angiotensin I
-
Oryctolagus cuniculus
3.4.15.1 2.3
-
hippuryl-Lys-Leu
-
Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zinc
-
Homo sapiens
3.4.15.1 Zinc contains approximately one molar equivalent of bound zinc Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.15.1 129000
-
equilibrium sedimentation Oryctolagus cuniculus
3.4.15.1 136000
-
glycerol density gradient centrifugation Oryctolagus cuniculus
3.4.15.1 140000
-
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Cavia porcellus
-
-
-
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Oryctolagus cuniculus
-
-
-
3.4.15.1 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.15.1 side-chain modification glycoprotein Cavia porcellus
3.4.15.1 side-chain modification glycoprotein Homo sapiens
3.4.15.1 side-chain modification glycoprotein Sus scrofa
3.4.15.1 side-chain modification glycoprotein Oryctolagus cuniculus
3.4.15.1 side-chain modification oligosaccharide accounts for 26% of the weight Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 lung
-
Cavia porcellus
-
3.4.15.1 lung
-
Homo sapiens
-
3.4.15.1 lung
-
Sus scrofa
-
3.4.15.1 lung
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
Cavia porcellus angiotensin II + His-Leu
-
?
3.4.15.1 angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
3.4.15.1 angiotensin I + H2O
-
Sus scrofa angiotensin II + His-Leu
-
?
3.4.15.1 angiotensin I + H2O about 5% of the activity with hippury-Lys-Leu Oryctolagus cuniculus angiotensin II + His-Leu
-
?
3.4.15.1 bradykinin + H2O
-
Cavia porcellus Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
3.4.15.1 bradykinin + H2O
-
Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
3.4.15.1 bradykinin + H2O
-
Sus scrofa Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
3.4.15.1 bradykinin + H2O about 3.5% of the activity with hippury-Lys-Leu Oryctolagus cuniculus Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
3.4.15.1 hippuryl-Lys-Leu + H2O
-
Oryctolagus cuniculus hippuric acid + Lys-Leu
-
?

Subunits

EC Number Subunits Comment Organism
3.4.15.1 ?
-
Homo sapiens
3.4.15.1 ?
-
Sus scrofa
3.4.15.1 ? x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.15.1 9.1
-
bradykinin
-
Oryctolagus cuniculus
3.4.15.1 13.2
-
angiotensin I
-
Oryctolagus cuniculus
3.4.15.1 257
-
hippuryl-His-Leu
-
Oryctolagus cuniculus