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Literature summary extracted from

  • Burg, R.W.; Snell, E.E.
    The bacterial oxidation of vitamin B6. VI. Pyridoxal dehydrogenase and 4-pyridoxolactonase (1969), J. Biol. Chem., 244, 2585-2589.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.107 5-Deoxypyridoxal stimulation Pseudomonas sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.107 2,2'-dipyridyl
-
 Pseudomonas sp.
1.1.1.107 4-pyridoxate
-
 Pseudomonas sp.
1.1.1.107 4-Pyridoxolactone
-
 Pseudomonas sp.
1.1.1.107 8-hydroxyquinoline
-
 Pseudomonas sp.
1.1.1.107 HgCl2
-
 Pseudomonas sp.
1.1.1.107 m-phenanthroline
-
 Pseudomonas sp.
1.1.1.107 o-phenanthroline
-
 Pseudomonas sp.
1.1.1.107 p-phenanthroline
-
 Pseudomonas sp.
1.1.1.107 pyridoxamine
-
 Pseudomonas sp.
1.1.1.107 pyridoxine
-
 Pseudomonas sp.
1.1.1.107 Quinoline
-
 Pseudomonas sp.
3.1.1.27 1,10-phenanthroline
-
 Pseudomonas sp.
3.1.1.27 1,7-phenanthroline
-
 Pseudomonas sp.
3.1.1.27 4-Pyridoxolactone substrate inhibition above 0. 02 mM Pseudomonas sp.
3.1.1.27 p-phenanthroline
-
 Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.107 0.076
-
 pyridoxal
-
 Pseudomonas sp.
1.1.1.107 0.29
-
 NAD+
-
 Pseudomonas sp.
3.1.1.27 0.0031
-
 4-Pyridoxolactone
-
 Pseudomonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.107 pyridoxal + NAD+ Pseudomonas sp.
-
 4-pyridoxolactone + NADH + H+
-
 ir
3.1.1.27 4-Pyridoxolactone + H2O Pseudomonas sp. vitamin B6 degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.107 Pseudomonas sp.
-
-
-
3.1.1.27 Pseudomonas sp.
-
 MA-1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.107 partial Pseudomonas sp.
3.1.1.27
-
 Pseudomonas sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.107 2-demethyl-2-ethylpyridoxal + NAD+
-
 Pseudomonas sp. ? + NADH
-
 ?
1.1.1.107 pyridoxal + NAD+
-
 Pseudomonas sp. 4-pyridoxolactone + NADH + H+
-
 ir
3.1.1.27 4-pyridoxolactone + H2O
-
 Pseudomonas sp. 4-pyridoxate
-
 ?
3.1.1.27 4-Pyridoxolactone + H2O vitamin B6 degradation Pseudomonas sp. ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.107 9.3 9.5
-
 Pseudomonas sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.107 6.1
-
 not active below Pseudomonas sp.
3.1.1.27 4 10
-
 Pseudomonas sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.107 NAD+
-
 Pseudomonas sp.