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Literature summary extracted from

  • Matsusaka, H.; Fukuda, M.; Elakhdar, A.; Kumamaru, T.
    Serine hydroxymethyltransferase participates in the synthesis of cysteine-rich storage proteins in rice seed (2021), Plant Sci., 312, 111049.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.1 gene LCRP, DNA and amino acid sequence determination and analysis, generation of a genetic linkage map of the LCRP gene Oryza sativa Japonica Group

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.1 additional information the lcrp mutation is induced by treatment with N-methyl-N-nitrosourea (MNU), resulting in the reduction of prolamines and alpha-globulin levels in rice seeds. Mutant lcrp lines have a decreased level of CysR proteins, analysis of lcrp mutant lines EM49, EM811, EM1367, EM1593, and PM1031. Genotyping and DNA and amino acid sequence analysis of lcrp mutants, overview Oryza sativa Japonica Group

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 tetrahydrofolate + L-serine Oryza sativa Japonica Group
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Oryza sativa Japonica Group
-
 cvs. Kinmaze and Taichung 65
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 leaf
-
 Oryza sativa Japonica Group
-
2.1.2.1 seed
-
 Oryza sativa Japonica Group
-
2.1.2.1 seedling
-
 Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 tetrahydrofolate + L-serine
-
 Oryza sativa Japonica Group 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 LCRP
-
 Oryza sativa Japonica Group
2.1.2.1 serine hydroxymethyltransferase
-
 Oryza sativa Japonica Group
2.1.2.1 SHMT
-
 Oryza sativa Japonica Group
2.1.2.1 SHMT4
-
 Oryza sativa Japonica Group

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 5,10-methylenetetrahydrofolate
-
 Oryza sativa Japonica Group
2.1.2.1 pyridoxal 5'-phosphate
-
 Oryza sativa Japonica Group
2.1.2.1 tetrahydrofolate
-
 Oryza sativa Japonica Group

General Information

EC Number General Information Comment Organism
2.1.2.1 malfunction the low level of cysteine-rich proteins (lcrp) mutation indicates a decrease in cysteine-rich (CysR) prolamines, alpha-globulin, and glutelin. The levels of L-Ser, Gly, and Met in the sulfur assimilation pathway in the lcrp seeds increase significantly compared to that in the wild-type. The lcrp mutation influences the growth of shoot and root. Accumulation of cysteine-poor prolamines in the lcrp seeds. Glutelin-containing protein bodies (PBs) are smaller and distorted in the lcrp seeds compared to those in the wild-type Oryza sativa Japonica Group
2.1.2.1 metabolism the serine hydroxymethyltransferase participates in glycine-serine interconversion of one-carbon metabolism in the sulfur assimilation pathway. Cysteine-rich proteins play an important role in the formation of protein bodies in rice Oryza sativa Japonica Group
2.1.2.1 physiological function gene LCRP encodes a serine hydroxymethyltransferase, which participates in glycine-serine interconversion of one-carbon metabolism in the sulfur assimilation pathway. The serine hydroxymethyltransferase participates in the synthesis of cysteine-rich storage proteins in rice seed Oryza sativa Japonica Group