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Literature summary extracted from

  • Zhao, D.; Yao, Z.; Zhang, J.; Zhang, R.; Mou, Z.; Zhang, X.; Li, Z.; Feng, X.; Chen, S.; Reiter, R.J.
    Melatonin synthesis genes N-acetylserotonin methyltransferases evolved into caffeic acid O-methyltransferases and both assisted in plant terrestrialization (2021), J. Pineal Res., 71, e12737.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin Oryza sativa Japonica Group
-
 S-adenosyl-L-homocysteine + melatonin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.4 Arabidopsis thaliana Q9FK25 cf. EC 2.1.1.68, EC 2.1.1.42
-
2.1.1.4 Oryza sativa Japonica Group Q6EPG8
-
-
2.1.1.42 Arabidopsis thaliana Q9FK25 cf. EC 2.1.1.68, Ec 2.1.1.4
-
2.1.1.68 Arabidopsis thaliana Q9FK25 cf. EC 2.1.1.4, Ec 2.1.1.42
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Oryza sativa Japonica Group S-adenosyl-L-homocysteine + melatonin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.4 ASMT1
-
 Oryza sativa Japonica Group
2.1.1.4 At5g54160
-
 Arabidopsis thaliana
2.1.1.4 N-acetylserotonin methyltransferase
-
 Oryza sativa Japonica Group
2.1.1.42 At5g54160
-
 Arabidopsis thaliana
2.1.1.68 At5g54160
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.4 S-adenosyl-L-methionine
-
 Oryza sativa Japonica Group

General Information

EC Number General Information Comment Organism
2.1.1.4 evolution caffeic acid O-methyltransferase likely evolved from N-acetylserotonin methyltransferase by gene duplication and subsequent divergence. Caffeic acid O-methyltransferase gained a significantly higher N-acetylserotonin methyltransferase activity to produce greater amounts of melatonin for immobile plants to acclimate to the land environments. The caffeic acid O-methyltransferase genes possess more conserved substrate-binding sites at the amino acid level and more open protein conformation compared to N-acetylserotonin methyltransferase genes Arabidopsis thaliana
2.1.1.42 evolution caffeic acid O-methyltransferase likely evolved from N-acetylserotonin methyltransferase by gene duplication and subsequent divergence. Caffeic acid O-methyltransferase gained a significantly higher N-acetylserotonin methyltransferase activity to produce greater amounts of melatonin for immobile plants to acclimate to the land environments. The caffeic acid O-methyltransferase genes possess more conserved substrate-binding sites at the amino acid level and more open protein conformation compared to N-acetylserotonin methyltransferase genes Arabidopsis thaliana
2.1.1.68 evolution caffeic acid O-methyltransferase likely evolved from N-acetylserotonin methyltransferase by gene duplication and subsequent divergence. Caffeic acid O-methyltransferase gained a significantly higher N-acetylserotonin methyltransferase activity to produce greater amounts of melatonin for immobile plants to acclimate to the land environments. The caffeic acid O-methyltransferase genes possess more conserved substrate-binding sites at the amino acid level and more open protein conformation compared to N-acetylserotonin methyltransferase genes Arabidopsis thaliana