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Literature summary extracted from
- Identification and functional analysis of GTP cyclohydrolase II in Candida glabrata in response to nitrosative stress (2022), Front. Microbiol., 13, 825121.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.25 | GTP + 4 H2O | Nakaseomyces glabratus | - |
formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate | - |
? |  |
| 3.5.4.25 | GTP + 4 H2O | Nakaseomyces glabratus KUE100-1 | - |
formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.25 | Nakaseomyces glabratus | Q6FUD7 | - |
- |
| 3.5.4.25 | Nakaseomyces glabratus KUE100-1 | Q6FUD7 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.25 | GTP + 4 H2O | - |
Nakaseomyces glabratus | formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate | - |
? | |
| 3.5.4.25 | GTP + 4 H2O | - |
Nakaseomyces glabratus KUE100-1 | formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.4.25 | gch2 | - |
Nakaseomyces glabratus |
| 3.5.4.25 | RIB1 | - |
Nakaseomyces glabratus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.5.4.25 | drug target | Candida glabrata is an opportunistic pathogen causing candidiasis especially in patients with immunocompromised state. The GCH2-dependent nitrosative stress detoxifying mechanism is a promising target for the development of novel antifungals | Nakaseomyces glabratus |
| 3.5.4.25 | physiological function | the enzyme confers nitrosative stress resistance on yeast cells. The proliferation of Candida glabrata in cultures of macrophage-like cells required the GCH2-dependent nitrosative stress detoxifying mechanism | Nakaseomyces glabratus |
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