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Literature summary extracted from

  • Buffon, G.; Lamb, T.I.; Lopes, M.C.B.; Sperotto, R.A.; Timmers, L.F.S.M.
    Push it to the limit Identification of novel amino acid changes on the acetolactate synthase enzyme of rice that putatively confer high level of tolerance to different imidazolinones (2020), Front. Bioeng. Biotechnol., 8, 73.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.2.1.6 agriculture to obtain a rice cultivar capable to tolerate imidazolinone inhibitors mazapic, imazapyr, imazaquin, imazethapyr at the same time, amino acid mutations at positions Val170, Phe180, Lys230, Arg351, Trp548, and Ser627 in the ALS1 are suggested Oryza sativa Japonica Group

Protein Variants

EC Number Protein Variants Comment Organism
2.2.1.6 F180A/K230A/R351A/W548A mutations decrease the estimated free energy of binding by 67% for imazapic, 62% for imazaquin, and 64% for imazethapyr Oryza sativa Japonica Group
2.2.1.6 K230A mutation decreases the affinity to imazapic, imazaquin, and imazethapyr by approximately 31, 31, and 30%, respectively Oryza sativa Japonica Group
2.2.1.6 K230A/R351A/W548A mutations decrease the estimated free energy of binding for imazapic, imazaquin, and imazethapyr Oryza sativa Japonica Group
2.2.1.6 K230A/W548A mutations decrease the estimated free energy of binding for imazapic, imazaquin, and imazethapyr Oryza sativa Japonica Group
2.2.1.6 W548A mutation decreases the affinity to imazapic, imazaquin, and imazethapyr by approximately 24, 22, and 25%, respectively Oryza sativa Japonica Group

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.6 imazapyr residues A96, P171, A179, W548, and S627 participate in binding, their mutation commonly confers resistance Oryza sativa Japonica Group
2.2.1.6 imazaquin residues A96, P171, A179, W548, and S627 participate in binding, their mutation commonly confers resistance Oryza sativa Japonica Group
2.2.1.6 imazethapyr residues A96, P171, A179, W548, and S627 participate in binding, their mutation commonly confers resistance Oryza sativa Japonica Group
2.2.1.6 mazapic residues A96, P171, A179, W548, and S627 participate in binding, their mutation commonly confers resistance Oryza sativa Japonica Group

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.2.1.6 chloroplast
-
 Oryza sativa Japonica Group 9507
-

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Oryza sativa Japonica Group Q6K2E8
-
-

Synonyms

EC Number Synonyms Comment Organism
2.2.1.6 ALS1
-
 Oryza sativa Japonica Group
2.2.1.6 Os02g30630
-
 Oryza sativa Japonica Group