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Literature summary extracted from

  • Demars, A.; Vitali, A.; Comein, A.; Carlier, E.; Azouz, A.; Goriely, S.; Smout, J.; Flamand, V.; Van Gysel, M.; Wouters, J.; Abendroth, J.; Edwards, T.E.; Machelart, A.; Hoffmann, E.; Brodin, P.; De Bolle, X.; Muraille, E.
    Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice (2021), PLoS Pathog., 17, e1009887.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.6 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.6 cis-aconitate Mus musculus
-
 itaconate + CO2
-
 ?
4.1.1.6 cis-aconitate Mus musculus C57BL/6
-
 itaconate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.6 Mus musculus P54987
-
-
4.1.1.6 Mus musculus C57BL/6 P54987
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.6 alveolar macrophage
-
 Mus musculus
-
4.1.1.6 lung
-
 Mus musculus
-
4.1.1.6 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.6 cis-aconitate
-
 Mus musculus itaconate + CO2
-
 ?
4.1.1.6 cis-aconitate
-
 Mus musculus C57BL/6 itaconate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.6 ACOD1
-
 Mus musculus
4.1.1.6 aconitate decarboxylase 1
-
 Mus musculus
4.1.1.6 immune responsive gene 1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
4.1.1.6 Mus musculus the aconitate decarboxylase 1 gene (Acod1, also known as Immune responsive gene 1) is one of the genes most upregulated in murine alveolar macrophages (AMs) in response to Brucella melitensis infection at 24 hours post-infection up

General Information

EC Number General Information Comment Organism
4.1.1.6 malfunction Acod1-/- C57BL/6 mice display a higher bacterial load in their lungs than wild-type mice following Brucella melitensis or Brucella abortus infection. Enhanced susceptibility of Brucella-infected Acod1-/- mice is not associated with higher inflammation in the lungs Mus musculus
4.1.1.6 physiological function the ACOD1 enzyme is mostly produced in mitochondria of macrophages, and converts cis-aconitate, a metabolite in the Krebs cycle, into itaconate. Acod1 participates in the control of pulmonary Brucella infection Mus musculus