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Literature summary extracted from

  • Liu, L.; Ren, M.; Peng, P.; Chun, Y.; Li, L.; Zhao, J.; Fang, J.; Peng, L.; Yan, J.; Chu, J.; Wang, Y.; Yuan, S.; Li, X.
    MIT1, encoding a 15-cis-zeta-carotene isomerase, regulates tiller number and stature in rice (2021), J. Genet. Genomics, 48, 88-91.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.2.1.12 gene MIT1, Map-based cloning reveals that MIT1 encodes Z-ISO Oryza sativa Japonica Group

Protein Variants

EC Number Protein Variants Comment Organism
5.2.1.12 additional information based on the single-nucleotide polymorphism G2674A in the coding sequence and a 46-bp InDel in 3'-UTR, three haplotypes of the MIT1 gene are constructed. Accessions of Hap2 has significantly more tillers and lower MIT1 expression than the other two haplotypes. The increased tiller phenotype is caused by the strigolactone (SL) deficiency. MIT1 controls tiller number through the SL pathway MIT1 is located upstream of the SL biosynthesis and signaling Oryza sativa Japonica Group

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.2.1.12 chloroplast membrane
-
 Oryza sativa Japonica Group 31969
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.2.1.12 9,15,9'-tricis-zeta-carotene Oryza sativa Japonica Group
-
 9,9'-dicis-zeta-carotene
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.2.1.12 Oryza sativa Japonica Group Q2QT64
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.2.1.12 bud
-
 Oryza sativa Japonica Group
-
5.2.1.12 additional information Z-ISO is expressed in most tissues Oryza sativa Japonica Group
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5.2.1.12 seedling
-
 Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.2.1.12 9,15,9'-tricis-zeta-carotene
-
 Oryza sativa Japonica Group 9,9'-dicis-zeta-carotene
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.2.1.12 15-cis-zeta-carotene isomerase
-
 Oryza sativa Japonica Group
5.2.1.12 MIT1
-
 Oryza sativa Japonica Group
5.2.1.12 Z-ISO
-
 Oryza sativa Japonica Group

General Information

EC Number General Information Comment Organism
5.2.1.12 malfunction rice mit1 mutant produces moderately increased tiller number with mildly reduced stature. Dark-grown mit1 plants accumulate higher levels of 9,15,9'-tri-cis-zeta-carotene, the substrate of ZISO, due to its inability to convert into 9,9'-di-cis-zeta-carotene. Even in tissues of the light-grown mit1 mutant, the contents of several carotenoids are also reduced. MIT1 deficiency leads to reduced carotenoid biosynthesis. Levels of epi-5DS, a native strigolactone (SL) in rice, are significantly lower in root exudates of mit1 seedlings than in the wild-type. The enhanced tiller bud outgrowth and mesocotyl elongation of mit1 are inhibited by application of the synthetic SL analogue GR24. SL-deficient rice mutants also exhibit accelerated mesocotyl elongation in dark-grown seedlings Oryza sativa Japonica Group
5.2.1.12 physiological function 15-cis-zeta-carotene isomerase (Z-ISO) is a key enzyme located in chloroplast membranes, where it independently catalyzes isomerization from 9,15,9'-tri-cis-zeta-carotene to 9,9'-di-cis-zeta-carotene. Its function can also be partially compensated by light. Map-based cloning reveals that gene MIT1 encodes Z-ISO in the carotenoid biosynthesis pathway Oryza sativa Japonica Group