Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhang, C.; Chen, X.; Lee, R.; Rehka, T.; Maurer-Stroh, S.; Rühl, M.
    Bioinformatics-aided identification, characterization and applications of mushroom linalool synthases (2021), Commun. Biol., 4, 223.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.3.26 synthesis linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products Cyclocybe aegerita
4.2.3.26 synthesis linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products Agrocybe pediades

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.26 expression in Escherichia coli Bl21-Gold DE3 Agrocybe pediades
4.2.3.26 expression in Escherichia coli Bl21-Gold DE3 Cyclocybe aegerita

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.26 0.0038
-
 geranyl diphosphate 37°C, pH not specified in the publication, Agrped1_689675, monofunctional linalool synthase Agrocybe pediades
4.2.3.26 0.0067
-
 geranyl diphosphate 37°C, pH not specified in the publication Cyclocybe aegerita

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.26 geranyl diphosphate + H2O Cyclocybe aegerita the bifunctional enzyme is also able to convert farnesyl diphosphate into nerolidol (3R)-linalool + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.26 Agrocybe pediades
-
-
-
4.2.3.26 Cyclocybe aegerita A0A872TMX7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.26
-
 Agrocybe pediades
4.2.3.26
-
 Cyclocybe aegerita

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.26 geranyl diphosphate + H2O the bifunctional enzyme is also able to convert farnesyl diphosphate into nerolidol Cyclocybe aegerita (3R)-linalool + diphosphate
-
 ?
4.2.3.26 geranyl diphosphate + H2O Agrped1_689671 is a bifunctional enzyme, which is also able to convert farnesyl diphosphate into nerolidol. Agrped1_689675 is a monofunctional linalool synthase Agrocybe pediades (3R)-linalool + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.26 AAE3_109435
-
 Cyclocybe aegerita
4.2.3.26 Agrped1_689671 gene name, bifunctional linalool/nerolidol synthase is also able to convert farnesyl diphosphate into nerolidol Agrocybe pediades
4.2.3.26 Agrped1_689675 gene name, monofunctional linalool synthase Agrocybe pediades

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.3.26 0.0083
-
 geranyl diphosphate 37°C, pH not specified in the publication Cyclocybe aegerita
4.2.3.26 0.1
-
 geranyl diphosphate 37°C, pH not specified in the publication, Agrped1_689675, monofunctional linalool synthase Agrocybe pediades

General Information

EC Number General Information Comment Organism
4.2.3.26 evolution phylogenetic analysis indicates clear divergence among the 35 plant enzymes (4 nerolidol synthases, 9 linalool synthases, and 22 linalool/nerolidol synthases), 1 bacterial linalool synthase (D5SL78), and 9 fungal enzymes (linalool/nerolidol synthases and linalool synthases) Cyclocybe aegerita
4.2.3.26 evolution phylogenetic analysis indicates clear divergence among the 35 plant enzymes (4 nerolidol synthases, 9 linalool synthases, and 22 linalool/nerolidol synthases), 1 bacterial linalool synthase (D5SL78), and 9 fungal enzymes (linalool/nerolidol synthases and linalool synthases) Agrocybe pediades

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.3.26 0.124
-
 geranyl diphosphate 37°C, pH not specified in the publication Cyclocybe aegerita
4.2.3.26 26.3
-
 geranyl diphosphate 37°C, pH not specified in the publication, Agrped1_689675, monofunctional linalool synthase Agrocybe pediades