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Literature summary extracted from

  • Lavhale, S.G.; Kalunke, R.M.; Giri, A.P.
    Structural, functional and evolutionary diversity of 4-coumarate-CoA ligase in plants (2018), Planta, 248, 1063-1078.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.2.1.12 biofuel production enzyme silencing can be used to improve lignocellulosic raw material for biofuel production Populus tremuloides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.12 ATP + 4-coumarate + CoA Robinia pseudoacacia
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA Arabidopsis thaliana
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA Populus euphratica
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA Oryza sativa Japonica Group
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA Physcomitrium patens
-
 AMP + diphosphate + 4-coumaroyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.12 Arabidopsis thaliana Q42524 isoform 4CL1
-
6.2.1.12 Arabidopsis thaliana Q9S725 isoform 4CL2
-
6.2.1.12 Arabidopsis thaliana Q9S777 isoform 4CL3
-
6.2.1.12 Arabidopsis thaliana Q84P26 isoform AMPd4CLlp
-
6.2.1.12 Oryza sativa Japonica Group Q6ETN3 isoform 4CL3
-
6.2.1.12 Oryza sativa Japonica Group Q6ZAC1 isoform 4CL5
-
6.2.1.12 Oryza sativa Japonica Group P17814 isoform 4CL1
-
6.2.1.12 Oryza sativa Japonica Group Q42982 isoform 4CL2
-
6.2.1.12 Oryza sativa Japonica Group Q67W82 isoform 4CL4
-
6.2.1.12 Physcomitrium patens
-
-
-
6.2.1.12 Populus euphratica
-
-
-
6.2.1.12 Populus tremuloides O81140 isoform 4CL2
-
6.2.1.12 Populus tremuloides O81139 isoform 4CL1
-
6.2.1.12 Robinia pseudoacacia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.12 leaf isoform 4CL2 is expressed in epidermal layers of leaf Populus tremuloides
-
6.2.1.12 stem isoform 4CL2 is expressed in epidermal layers of stem Populus tremuloides
-
6.2.1.12 xylem
-
 Robinia pseudoacacia
-
6.2.1.12 xylem isoform 4CL1 is specifically expressed in lignin-containing tissue such as xylem Populus tremuloides
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.12 ATP + 4-coumarate + CoA
-
 Robinia pseudoacacia AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA
-
 Arabidopsis thaliana AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA
-
 Populus euphratica AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA
-
 Oryza sativa Japonica Group AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA
-
 Physcomitrium patens AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA preferred substrate of isoform 4CL1. Isoforms 4CL2 and 4CL3 also show high activity with 4-coumarate Robinia pseudoacacia AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA best substrate for isoform 4CL2 Populus tremuloides AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA
-
 Populus tremuloides AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 5-hydroxyferulate + CoA
-
 Populus tremuloides AMP + diphosphate + 5-hydroxyferuloyl-CoA
-
 ?
6.2.1.12 ATP + 5-hydroxyferulate + CoA best substrate for isoform 4CL1 Populus tremuloides AMP + diphosphate + 5-hydroxyferuloyl-CoA
-
 ?
6.2.1.12 ATP + caffeate + CoA isoforms 4CL2 and 4CL3 show high activity with caffeate Robinia pseudoacacia AMP + diphosphate + caffeoyl-CoA
-
 ?
6.2.1.12 ATP + sinapate + CoA isoforms 4CL2 and 4CL3 show high activity with sinapate Robinia pseudoacacia AMP + diphosphate + sinapoyl-CoA
-
 ?
6.2.1.12 additional information isoform 4CL1 is unable to utilize ferulate and sinapate Robinia pseudoacacia ?
-
 ?
6.2.1.12 additional information isoform 4CL2 is inactive with 5-hydroxyferulate Populus tremuloides ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.12 4-coumarate-CoA ligase
-
 Robinia pseudoacacia
6.2.1.12 4-coumarate-CoA ligase
-
 Arabidopsis thaliana
6.2.1.12 4-coumarate-CoA ligase
-
 Populus euphratica
6.2.1.12 4-coumarate-CoA ligase
-
 Populus tremuloides
6.2.1.12 4-coumarate-CoA ligase
-
 Oryza sativa Japonica Group
6.2.1.12 4-coumarate-CoA ligase
-
 Physcomitrium patens
6.2.1.12 4-coumarate:CoA ligase
-
 Robinia pseudoacacia
6.2.1.12 4-coumarate:CoA ligase
-
 Arabidopsis thaliana
6.2.1.12 4-coumarate:CoA ligase
-
 Populus euphratica
6.2.1.12 4-coumarate:CoA ligase
-
 Populus tremuloides
6.2.1.12 4-coumarate:CoA ligase
-
 Oryza sativa Japonica Group
6.2.1.12 4-coumarate:CoA ligase
-
 Physcomitrium patens
6.2.1.12 4CL1 isoform Robinia pseudoacacia
6.2.1.12 4CL1 isoform Arabidopsis thaliana
6.2.1.12 4CL1 isoform Oryza sativa Japonica Group
6.2.1.12 4CL1 isoform Physcomitrium patens
6.2.1.12 4CL1 isoform Populus tremuloides
6.2.1.12 4CL10 isoform Populus euphratica
6.2.1.12 4CL11 isoform Populus euphratica
6.2.1.12 4CL12 isoform Populus euphratica
6.2.1.12 4CL2 isoform Robinia pseudoacacia
6.2.1.12 4CL2 isoform Arabidopsis thaliana
6.2.1.12 4CL2 isoform Populus euphratica
6.2.1.12 4CL2 isoform Populus tremuloides
6.2.1.12 4CL2 isoform Oryza sativa Japonica Group
6.2.1.12 4CL2 isoform Physcomitrium patens
6.2.1.12 4CL3 isoform Robinia pseudoacacia
6.2.1.12 4CL3 isoform Arabidopsis thaliana
6.2.1.12 4CL3 isoform Oryza sativa Japonica Group
6.2.1.12 4CL3 isoform Physcomitrium patens
6.2.1.12 4CL4 isoform Oryza sativa Japonica Group
6.2.1.12 4CL5 isoform Populus euphratica
6.2.1.12 4CL5 isoform Oryza sativa Japonica Group
6.2.1.12 4CL9 isoform Populus euphratica
6.2.1.12 AMP dependent 4CL like protein
-
 Arabidopsis thaliana
6.2.1.12 AMPd4CLlp isoform Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
6.2.1.12 Populus euphratica the expression of isoform 4CL5 is downregulated by NaCl stress down
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL5 is downregulated by UV radiation down
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL1 is downregulated by wounding down
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL2 is downregulated by wounding down
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL3 is downregulated by UV radiation down
6.2.1.12 Oryza sativa Japonica Group the expression of isoforms 4CL4 is downregulated by UV radiation down
6.2.1.12 Arabidopsis thaliana the expression of isoform 4CL3 is not changed by Peronospora parasitica infection and wounding additional information
6.2.1.12 Populus euphratica the expression of isoforms 4CL9 and 4CL10 is not changed by NaCl stress additional information
6.2.1.12 Arabidopsis thaliana the expression of isoform 4CL1 is induced by wounding and methyl jasmonate as well as Peronospora parasitica infection and wounding up
6.2.1.12 Arabidopsis thaliana the expression of isoform 4CL2 is induced by wounding and methyl jasmonate as well as Peronospora parasitica infection and wounding up
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL5 is induced by wounding up
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL1 is induced by UV radiation up
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL3 is induced by wounding up
6.2.1.12 Oryza sativa Japonica Group the expression of isoform 4CL4 is induced by wounding up
6.2.1.12 Physcomitrium patens the enzyme expression is induced by treatment with absisic acid, methyl jasmonate and gallic acid up

General Information

EC Number General Information Comment Organism
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Robinia pseudoacacia
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Arabidopsis thaliana
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Populus euphratica
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Populus tremuloides
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Oryza sativa Japonica Group
6.2.1.12 physiological function the enzyme plays a role in biosynthesis of lignins, flavonoids, phenylpropanoids and other compounds for mechanical support, and protection from biotic and abiotic stresses Physcomitrium patens