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Literature summary extracted from

  • Lambert-Smith, I.; Saunders, D.; Yerbury, J.
    The pivotal role of ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration (2020), Int. J. Biochem. Cell Biol., 123, 105746.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.45 117849
-
 calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Homo sapiens
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.45 Homo sapiens P22314
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.45 additional information the enzyme (UBA1) exhibits ubiquitous expression throughout all human tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Homo sapiens AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.45 Uba1
-
 Homo sapiens
6.2.1.45 UBE1
-
 Homo sapiens
6.2.1.45 ubiquitin-activating enzyme E1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.2.1.45 malfunction impaired UBA1 activity in a range of neurodegenerative conditions, including Parkinson's disease, Alzheimer's disease, Huntington's disease and spinal muscular atrophy Homo sapiens
6.2.1.45 metabolism ubiquitin-activating enzyme E1, UBA1, functions at the apex of the enzymatic ubiquitylation cascade, catalysing ubiquitin activation. UBA1 is thus of fundamental importance to the modulation of ubiquitin homeostasis and to all downstream ubiquitylation-dependent cellular processes, including proteolysis through the ubiquitin-proteasome system and selective autophagy Homo sapiens
6.2.1.45 physiological function UBA1 is essential for autophagy in certain cell types Homo sapiens