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Literature summary extracted from

  • Wang, X.; Guo, L.; Zhang, S.; Chen, Y.; Chen, Y.T.; Zheng, B.; Sun, J.; Qian, Y.; Chen, Y.; Yan, B.; Lu, W.
    Copper sulfide facilitates hepatobiliary clearance of gold nanoparticles through the copper-transporting ATPase ATP7B (2019), ACS nano, 13, 5720-5730.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.2.2.8 medicine metallic gold nanoparticles have great potential for a wide variety of biomedical applications. Yet, slow clearance of Au nanoparticles significantly hinders their clinical translation. Copper sulfide facilitates hepatobiliary clearance of gold nanoparticles through the copper-transporting ATPase ATP7B. The CuS-Au conjugation approach provides a feasible strategy to enhance the hepatobiliary clearance of Au nanoparticles that may be applicable to various structures Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.8 plasma membrane
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 Mus musculus 5886
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Organism

EC Number Organism UniProt Comment Textmining
7.2.2.8 Mus musculus Q64446
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.8 hepatocyte
-
 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
7.2.2.8 ATP7B
-
 Mus musculus
7.2.2.8 Cu-transporting P-type ATPase
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 Mus musculus

General Information

EC Number General Information Comment Organism
7.2.2.8 physiological function the enzyme is crucial for maintaining Cu homeostasis. The efficient hepatobiliary excretion of CuS nanoparticles is attributed to the participation of Cu-transporting ATPase ATP7B. Due to slow release of Cu ions from the endocytosed CuS nanoparticles, ATP7B traverses the endolysosomal compartment to chelate intravesicular Cu, regulating both ionic and particulate Cu excretion into bile canaliculi Mus musculus