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Literature summary extracted from

  • Lee, B.; Lee, S.; Choo, M.; Kim, J.; Lee, H.; Kim, S.; Fomenko, D.; Kim, H.; Park, J.; Gladyshev, V.
    Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo /631/45/612 /631/250 /38 /82 /82/80 article (2017), Sci. Rep., 7, 5119 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.4.12 selenium selenoprotein Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Mus musculus Q9JLC3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.12 macrophage highly expressed in immune-activated macrophages Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 MSRB1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.8.4.12 Mus musculus lipopolysaccharide induces expression of MsrB1 up

General Information

EC Number General Information Comment Organism
1.8.4.12 drug target MsrB1-dependent reduction of oxidized methionine in proteins may be a regulatory event underlying immunity and inflammatory disease, and a novel target for clinical applications Mus musculus
1.8.4.12 malfunction genetic ablation of MsrB1 doesd not preclude LPS-induced intracellular signaling in macrophages, but results in attenuated induction of antiinflammatory cytokines, such as interleukin (IL)-10 and the IL-1 receptor antagonist Mus musculus
1.8.4.12 physiological function the enzyme (MsrB1) controls immune responses by promoting anti-inflammatory cytokine expression in macrophages Mus musculus