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Literature summary extracted from

  • Wells, M.; Kanmanii, N.J.; Al Zadjali, A.M.; Janecka, J.E.; Basu, P.; Oremland, R.S.; Stolz, J.F.
    Methane, arsenic, selenium and the origins of the DMSO reductase family (2020), Sci. Rep., 10, 10946 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.5.3 gene dmsA, DNA and amino acid sequence comparisons and phylogenetic analysis, detailed overview Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.5.3 Molybdenum required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.5.3 dimethylsulfoxide + menaquinol Escherichia coli
-
 dimethylsulfide + menaquinone + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.3 Escherichia coli P18775
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.3 dimethylsulfoxide + menaquinol
-
 Escherichia coli dimethylsulfide + menaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.5.3 dimethyl sulfoxide reductase
-
 Escherichia coli
1.8.5.3 DmsA
-
 Escherichia coli
1.8.5.3 DMSO reductase
-
 Escherichia coli
1.8.5.3 DMSOR
-
 Escherichia coli
1.8.5.3 respiratory dimethyl sulfoxide reductase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.5.3 molybdenum cofactor
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
1.8.5.3 evolution ubiquitous in Archaea and Bacteria, mononuclear molybdoenzymes of the dimethyl sulfoxide reductase (DMSOR) family are believed to have been core components of the first anaerobic respiratory chains, and thus present at life's origins. The family, which has been defined by the presence of a mononuclear molybdopterin or tungstopterin bis(pyranopterin guanine dinucleotide) (Mo/W-bisPGD) cofactor, is named after DMSO reductases, the first members of the family to be well-characterized. Phylogenetic analysis of DMSOR family clades and members, detailed overview. The enzyme belongs to a clade of DMSOR members that include the respiratory dimethyl sulfoxide reductase (DmsA), respiratory nitrate reductase (NarG), PsrA/PhsA/SrrA, ArxA/ArrA, and TtrA/SrdA/archaeal arsenate reductase lineages that interact with the membrane quinone pool during anaerobic respiration using the canonical subunits. The association of DMSOR members with characteristic electron transfer and membrane anchor subunits arose once early in the evolution of DSMORs and co-evolved with these representatives through multiple diversification events Escherichia coli