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Literature summary extracted from

  • Giarratana, N.; Conti, F.; La Rovere, R.; Gijsbers, R.; Carai, P.; Duelen, R.; Vervliet, T.; Bultynck, G.; Ronzoni, F.; Piciotti, R.; Costamagna, D.; Fulle, S.; Barravecchia, I.; Angeloni, D.; Torrente, Y.; Sampaolesi, M.
    MICAL2 is essential for myogenic lineage commitment (2020), Cell Death Dis., 11, 654.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.225 nucleus MICAL2 localizes in the nucleus of acute and chronic regenerating muscle fibers Mus musculus 5634
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Organism

EC Number Organism UniProt Comment Textmining
1.14.13.225 Mus musculus Q8BML1 isoform MICAL2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.225 C2C12 cell C2C12 and satellite cells require MICAL2 for myogenic differentiation Mus musculus
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1.14.13.225 muscle MICAL2 localizes in the nucleus of acute and chronic regenerating muscle fibers Mus musculus
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1.14.13.225 pluripotent stem cell MICAL2 expression increases during myogenic differentiation of adult and pluripotent stem cells Mus musculus
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1.14.13.225 satellite cell C2C12 and satellite cells require MICAL2 for myogenic differentiation Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
1.14.13.225 Mical2
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 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.13.225 physiological function MICAL2 is essential for skeletal muscle homeostasis and functionality. Lack of MICAL2 results in muscle actin defects. MICAL2 upregulation shows a positive impact on skeletal and cardiac muscle commitments Mus musculus