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Literature summary extracted from

  • Liu, J.; Wei, Y.; Ma, K.; An, J.; Liu, X.; Liu, Y.; Ang, E.; Zhao, H.; Zhang, Y.
    Mechanistically diverse pathways for sulfoquinovose degradation in bacteria (2021), ACS Catal., 11, 14740-14750.
No PubMed abstract available

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.1.31 intracellular
-
 Escherichia coli 5622
-
5.3.1.31 intracellular
-
 Priestia megaterium 5622
-
5.3.1.31 intracellular
-
 Alkalicoccus urumqiensis 5622
-
5.3.1.31 intracellular
-
 Clostridium sp. MSTE9 5622
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Clostridium sp. MSTE9
-
 isethionate + NAD+
-
 r
1.1.1.433 isethionate + NAD+ Clostridium sp. MSTE9
-
 2-sulfoacetaldehyde + NADH + H+
-
 r
2.2.1.15 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate Clostridium sp. MSTE9
-
 D-xylulose-5-phosphate + sulfoacetaldehyde
-
 ?
2.2.1.15 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate Clostridium sp. MSTE9
-
 D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose
-
 ?
5.3.1.31 beta-sulfoquinovose Escherichia coli
-
 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose Priestia megaterium
-
 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose Alkalicoccus urumqiensis
-
 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose Clostridium sp. MSTE9
-
 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose Escherichia coli K12
-
 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.37 4-deoxy-4-sulfo-D-erythrose Clostridium sp. MSTE9
-
 4-deoxy-4-sulfo-D-erythrulose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.432 Novosphingobium aromaticivorans
-
-
-
1.1.1.433 Clostridium sp. MSTE9
-
-
-
2.2.1.15 Clostridium sp. MSTE9
-
-
-
5.3.1.31 Alkalicoccus urumqiensis
-
-
-
5.3.1.31 Clostridium sp. MSTE9
-
-
-
5.3.1.31 Escherichia coli P32140
-
-
5.3.1.31 Escherichia coli K12 P32140
-
-
5.3.1.31 Priestia megaterium
-
-
-
5.3.1.37 Clostridium sp. MSTE9
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.432 6-dehydro-D-glucose + NADPH + H+
-
 Novosphingobium aromaticivorans D-glucose + NADP+
-
 r
1.1.1.432 D-glucose + NADP+
-
 Novosphingobium aromaticivorans 6-dehydro-D-glucose + NADPH + H+
-
 r
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Clostridium sp. MSTE9 isethionate + NAD+
-
 r
1.1.1.433 isethionate + NAD+
-
 Clostridium sp. MSTE9 2-sulfoacetaldehyde + NADH + H+
-
 r
2.2.1.15 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate
-
 Clostridium sp. MSTE9 D-xylulose-5-phosphate + sulfoacetaldehyde
-
 ?
2.2.1.15 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate
-
 Clostridium sp. MSTE9 D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose
-
 ?
5.3.1.31 beta-sulfoquinovose
-
 Escherichia coli 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose
-
 Priestia megaterium 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose
-
 Alkalicoccus urumqiensis 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose
-
 Clostridium sp. MSTE9 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.31 beta-sulfoquinovose
-
 Escherichia coli K12 6-deoxy-6-sulfo-D-fructose
-
 r
5.3.1.37 4-deoxy-4-sulfo-D-erythrose
-
 Clostridium sp. MSTE9 4-deoxy-4-sulfo-D-erythrulose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.432 squF
-
 Novosphingobium aromaticivorans
1.1.1.433 sqwF
-
 Clostridium sp. MSTE9
2.2.1.15 sqwGH
-
 Clostridium sp. MSTE9
5.3.1.31 SQ isomerase
-
 Escherichia coli
5.3.1.31 SQ isomerase
-
 Priestia megaterium
5.3.1.31 SQ isomerase
-
 Alkalicoccus urumqiensis
5.3.1.31 SQ isomerase
-
 Clostridium sp. MSTE9
5.3.1.31 SqvD
-
 Priestia megaterium
5.3.1.31 SqvD
-
 Alkalicoccus urumqiensis
5.3.1.31 SqvD
-
 Clostridium sp. MSTE9
5.3.1.31 yihS
-
 Escherichia coli
5.3.1.37 SEu isomerase
-
 Clostridium sp. MSTE9
5.3.1.37 sqwI
-
 Clostridium sp. MSTE9

General Information

EC Number General Information Comment Organism
1.1.1.432 physiological function in Novosphingobium aromaticivorans, sulfoquinovose degradation involves oxygenolytic C-S cleavage by flavin-dependent alkanesulfonate monooxygenase SquD that catalyzes sulfoquinovose cleavage into sulfite and 6-dehydro-D-glucose. SquF is an NAD(P)-dependent D-glucose 6-dehydrogenase Novosphingobium aromaticivorans
1.1.1.433 evolution in diverse anaerobic bacteria including Firmicutes, Tenericutes, Spirochaetes, and Thermotogae bacteria, a sulfoquinone degradation pathway contains a mutarotase SqvB, an isomerase SqvD, a transketolase SqwGH, a homologue of ribose-5-phosphate isomerase SqwI, a metal-dependent alcohol dehydrogenase SqwF, and a member of the sulfite/sulfonate exporter family SqwE. This suggests a pathway involving isomerization of sulfoquinone to 6-deoxy-6-sulfofructose by SqvD, cleavage of 6-deoxy-6-sulfofructose by SqwGH, reduction of an aldehyde-containing sulfonate by SqwF, followed by export of the sulfonate end-product by SqwE Clostridium sp. MSTE9
2.2.1.15 evolution in diverse anaerobic bacteria including Firmicutes, Tenericutes, Spirochaetes, and Thermotogae bacteria, a sulfoquinone degradation pathway contains a mutarotase SqvB, an isomerase SqvD, a transketolase SqwGH, a homologue of ribose-5-phosphate isomerase SqwI, a metal-dependent alcohol dehydrogenase SqwF, and a member of the sulfite/sulfonate exporter family SqwE. This suggests a pathway involving isomerization of sulfoquinone to 6-deoxy-6-sulfofructose by SqvD, cleavage of 6-deoxy-6-sulfofructose by SqwGH, reduction of an aldehyde-containing sulfonate by SqwF, followed by export of the sulfonate end-product by SqwE Clostridium sp. MSTE9
5.3.1.31 metabolism the enzyme is involved in sulfoquinovose degradation. Sulfoquinovose (6-deoxy-6-sulfo-D-glucose, SQ) is the polar headgroup of sulfolipids present in plants and other photosynthetic organisms and is one of the most abundant organosulfur compounds in nature. Bacterial degradation of SQ, termed sulfoglycolysis, is thus an important part of the global sulfur cycle. Three sulfoglycolysis pathways have been reported to date, the first analogous to the Embden-Meyerhof-Parnas (sulfo-EMP) glycolytic pathway (reported in Gram-negative gamma-proteobacteria), the second analogous to the Entner-Doudoroff (sulfo-ED) glycolytic pathway, and the third involving a transaldolase (sulfo-TAL) related to that in the pentose phosphate pathway. Discovery of three additional sulfoglycolysis pathways, the first involving a transketolase (sulfo-TK) related to that in the pentose phosphate pathway, the second involving oxygenolytic C-S cleavage of SQ by a flavin-dependent alkanesulfonate monooxygenase (sulfo-ASMO), and the third being a variant of the sulfo-EMP pathway in Gram-positive bacteria (sulfo-EMP2). In all three sulfoglycolysis pathways, the SQ C1-C3 moiety is channeled into the carbon and energy metabolism of the respective bacteria. The SQ C4-C6 moiety is converted to SLA, which is subsequently reduced to dihydroxypropanesulfonate (DHPS) by the reduced nicotinamide adenine dinucleotide (NADH)-dependent SLA reductase (YihU) or oxidized to sulfolactate (SL) by the NAD+-dependent SLA dehydrogenase (SlaB). Bioinformatics investigation of SQ degradation gene clusters in bacteria, overview Escherichia coli
5.3.1.31 metabolism the enzyme is involved in sulfoquinovose degradation. Sulfoquinovose (6-deoxy-6-sulfo-D-glucose, SQ) is the polar headgroup of sulfolipids present in plants and other photosynthetic organisms and is one of the most abundant organosulfur compounds in nature. Bacterial degradation of SQ, termed sulfoglycolysis, is thus an important part of the global sulfur cycle. Three sulfoglycolysis pathways have been reported to date, the first analogous to the Embden-Meyerhof-Parnas (sulfo-EMP) glycolytic pathway (reported in Gram-negative gamma-proteobacteria), the second analogous to the Entner-Doudoroff (sulfo-ED) glycolytic pathway, and the third involving a transaldolase (sulfo-TAL) related to that in the pentose phosphate pathway. Discovery of three additional sulfoglycolysis pathways, the first involving a transketolase (sulfo-TK) related to that in the pentose phosphate pathway, the second involving oxygenolytic C-S cleavage of SQ by a flavin-dependent alkanesulfonate monooxygenase (sulfo-ASMO), and the third being a variant of the sulfo-EMP pathway in Gram-positive bacteria (sulfo-EMP2). In all three sulfoglycolysis pathways, the SQ C1-C3 moiety is channeled into the carbon and energy metabolism of the respective bacteria. The SQ C4-C6 moiety is converted to SLA, which is subsequently reduced to dihydroxypropanesulfonate (DHPS) by the reduced nicotinamide adenine dinucleotide (NADH)-dependent SLA reductase (YihU) or oxidized to sulfolactate (SL) by the NAD+-dependent SLA dehydrogenase (SlaB). Bioinformatics investigation of SQ degradation gene clusters in bacteria, overview Priestia megaterium
5.3.1.31 metabolism the enzyme is involved in sulfoquinovose degradation. Sulfoquinovose (6-deoxy-6-sulfo-D-glucose, SQ) is the polar headgroup of sulfolipids present in plants and other photosynthetic organisms and is one of the most abundant organosulfur compounds in nature. Bacterial degradation of SQ, termed sulfoglycolysis, is thus an important part of the global sulfur cycle. Three sulfoglycolysis pathways have been reported to date, the first analogous to the Embden-Meyerhof-Parnas (sulfo-EMP) glycolytic pathway (reported in Gram-negative gamma-proteobacteria), the second analogous to the Entner-Doudoroff (sulfo-ED) glycolytic pathway, and the third involving a transaldolase (sulfo-TAL) related to that in the pentose phosphate pathway. Discovery of three additional sulfoglycolysis pathways, the first involving a transketolase (sulfo-TK) related to that in the pentose phosphate pathway, the second involving oxygenolytic C-S cleavage of SQ by a flavin-dependent alkanesulfonate monooxygenase (sulfo-ASMO), and the third being a variant of the sulfo-EMP pathway in Gram-positive bacteria (sulfo-EMP2). In all three sulfoglycolysis pathways, the SQ C1-C3 moiety is channeled into the carbon and energy metabolism of the respective bacteria. The SQ C4-C6 moiety is converted to SLA, which is subsequently reduced to dihydroxypropanesulfonate (DHPS) by the reduced nicotinamide adenine dinucleotide (NADH)-dependent SLA reductase (YihU) or oxidized to sulfolactate (SL) by the NAD+-dependent SLA dehydrogenase (SlaB). Bioinformatics investigation of SQ degradation gene clusters in bacteria, overview Alkalicoccus urumqiensis
5.3.1.31 metabolism the enzyme is involved in sulfoquinovose degradation. Sulfoquinovose (6-deoxy-6-sulfo-D-glucose, SQ) is the polar headgroup of sulfolipids present in plants and other photosynthetic organisms and is one of the most abundant organosulfur compounds in nature. Bacterial degradation of SQ, termed sulfoglycolysis, is thus an important part of the global sulfur cycle. Three sulfoglycolysis pathways have been reported to date, the first analogous to the Embden-Meyerhof-Parnas (sulfo-EMP) glycolytic pathway (reported in Gram-negative gamma-proteobacteria), the second analogous to the Entner-Doudoroff (sulfo-ED) glycolytic pathway, and the third involving a transaldolase (sulfo-TAL) related to that in the pentose phosphate pathway. Discovery of three additional sulfoglycolysis pathways, the first involving a transketolase (sulfo-TK) related to that in the pentose phosphate pathway, the second involving oxygenolytic C-S cleavage of SQ by a flavin-dependent alkanesulfonate monooxygenase (sulfo-ASMO), and the third being a variant of the sulfo-EMP pathway in Gram-positive bacteria (sulfo-EMP2). In all three sulfoglycolysis pathways, the SQ C1-C3 moiety is channeled into the carbon and energy metabolism of the respective bacteria. The SQ C4-C6 moiety is converted to SLA, which is subsequently reduced to dihydroxypropanesulfonate (DHPS) by the reduced nicotinamide adenine dinucleotide (NADH)-dependent SLA reductase (YihU) or oxidized to sulfolactate (SL) by the NAD+-dependent SLA dehydrogenase (SlaB). Bioinformatics investigation of SQ degradation gene clusters in bacteria, overview Clostridium sp. MSTE9