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Literature summary extracted from

  • Xing, M.; Wei, Y.; Zhou, Y.; Zhang, J.; Lin, L.; Hu, Y.; Hua, G.; N. Nanjaraj Urs, A.; Liu, D.; Wang, F.; Guo, C.; Tong, Y.; Li, M.; Liu, Y.; Ang, E.; Zhao, H.; Yuchi, Z.; Zhang, Y.
    Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria (2019), Nat. Commun., 10, 1609.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.4.1.38 in complex with isethionate, to 2.4 A resolution. space group P21, crystals contain four monomers per asymmetric unit, each exhibiting a canonical beta/alpha barrel fold Nitratidesulfovibrio vulgaris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.38 44.8
-
 isethionate pH not specified in the publication, temperature not specified in the publication Nitratidesulfovibrio vulgaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia
-
 isethionate + NAD+
-
 ?
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia 3_1_6
-
 isethionate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.433 Bilophila wadsworthia E5Y946
-
-
1.1.1.433 Bilophila wadsworthia 3_1_6 E5Y946
-
-
4.4.1.38 Nitratidesulfovibrio vulgaris Q727N1
-
-
4.4.1.38 Nitratidesulfovibrio vulgaris ATCC 29579 Q727N1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia isethionate + NAD+
-
 ?
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia 3_1_6 isethionate + NAD+
-
 ?
4.4.1.38 isethionate
-
 Nitratidesulfovibrio vulgaris acetaldehyde + H+ + sulfite
-
 ?
4.4.1.38 isethionate
-
 Nitratidesulfovibrio vulgaris ATCC 29579 acetaldehyde + H+ + sulfite
-
 ?
4.4.1.38 additional information no substrates: taurine or ethanolamine Nitratidesulfovibrio vulgaris ?
-
 ?
4.4.1.38 additional information no substrates: taurine or ethanolamine Nitratidesulfovibrio vulgaris ATCC 29579 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.433 tauF
-
 Bilophila wadsworthia
4.4.1.38 GUF
-
 Nitratidesulfovibrio vulgaris
4.4.1.38 IseG
-
 Nitratidesulfovibrio vulgaris

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4.1.38 91.6
-
 isethionate pH not specified in the publication, temperature not specified in the publication Nitratidesulfovibrio vulgaris

General Information

EC Number General Information Comment Organism
1.1.1.433 physiological function involved in taurine degradation in human gut. TauF catalyzes NADH-dependent reduction of sulfoacetaldehyde, generating isethionate that is subsequently cleaved by sulfonate C-S lyase IseG Bilophila wadsworthia