Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Andrade-Pavon, D.; Ortiz-Alvarez, J.; Sanchez-Sandoval, E.; Tamariz, J.; Hernandez-Rodriguez, C.; Ibarra, J.A.; Villa-Tanaca, L.
    Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by alpha-asarone-based synthetic compounds as antifungal agents (2019), J. Biotechnol., 292, 64-67 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 alpha-asarone 9.4% inhibition at 0.1 mM Nakaseomyces glabratus
1.1.1.34 methyl (2-methoxy-5-nitro-4-propylphenoxy)acetate 96.8% inhibition at 0.1 mM Nakaseomyces glabratus
1.1.1.34 methyl (4-ethyl-2-nitrophenoxy)acetate 84.9% inhibition at 0.1 mM Nakaseomyces glabratus
1.1.1.34 simvastatin
-
 Nakaseomyces glabratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Nakaseomyces glabratus
-
 (R)-mevalonate + CoA + 2 NADP+
-
 ?
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Nakaseomyces glabratus CBS138
-
 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Nakaseomyces glabratus
-
-
-
1.1.1.34 Nakaseomyces glabratus CBS138
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Nakaseomyces glabratus (R)-mevalonate + CoA + 2 NADP+
-
 ?
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Nakaseomyces glabratus CBS138 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA reductase
-
 Nakaseomyces glabratus
1.1.1.34 HMGR
-
 Nakaseomyces glabratus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.34 0.02877
-
 at pH 8.0 and 37°C Nakaseomyces glabratus methyl (4-ethyl-2-nitrophenoxy)acetate
1.1.1.34 0.04265
-
 at pH 8.0 and 37°C Nakaseomyces glabratus methyl (2-methoxy-5-nitro-4-propylphenoxy)acetate