Literature summary extracted from

Sumner, J.; Matthews, R.
Stereochemistry and mechanism of hydrogen transfer between NADPH and methylenetetrahydrofolate in the reaction catalyzed by methylenetetrahydrofolate reductase from pig liver (1992), J. Am. Chem. Soc., 114, 6949-6956 .

No PubMed abstract available

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.53	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.5.1.53	liver	-	Sus scrofa	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.5.1.53	5,10-methylenetetrahydrofolate + NADPH + H+	-	Sus scrofa	5-methyltetrahydrofolate + NADP+	-	?

General Information

EC Number	General Information	Comment	Organism
1.5.1.53	metabolism	Methylenetetrahydrofolate reductase presents reacts with both NADPH and 5,10-methylenetetrahydrofolate at the si face. The reaction involves successive hydride transfers to and from the flavin cofactor. NADP+ dissociates before 5,10-methylenetetrahydrofolate binds the reduced enzyme	Sus scrofa

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Release 2023.1 (January 2023)