Literature summary extracted from

Gautam, L.K.; Sharma, P.; Capalash, N.
Bacterial polyphosphate kinases revisited role in pathogenesis and therapeutic potential (2019), Curr. Drug Targets, 20, 292-301 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.4.1	Bacillus cereus	-	-	-
2.7.4.1	Escherichia coli	-	-	-
2.7.4.1	Escherichia coli K1 (RS218)	-	-	-
2.7.4.1	Francisella tularensis	-	-	-
2.7.4.1	Helicobacter pylori	-	-	-
2.7.4.1	Neisseria meningitidis	-	-	-
2.7.4.1	Porphyromonas gingivalis	-	-	-
2.7.4.1	Proteus mirabilis	-	-	-
2.7.4.1	Pseudomonas aeruginosa	-	-	-
2.7.4.1	Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.4.1	PPK	-	Salmonella enterica subsp. enterica serovar Typhimurium
2.7.4.1	PPK	-	Proteus mirabilis
2.7.4.1	PPK	-	Porphyromonas gingivalis
2.7.4.1	PPK1	-	Escherichia coli
2.7.4.1	PPK1	-	Pseudomonas aeruginosa
2.7.4.1	PPK1	-	Neisseria meningitidis
2.7.4.1	PPK1	-	Helicobacter pylori
2.7.4.1	PPK2	-	Pseudomonas aeruginosa
2.7.4.1	PPK2	-	Francisella tularensis

General Information

EC Number	General Information	Comment	Organism
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Salmonella enterica subsp. enterica serovar Typhimurium
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Escherichia coli
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Pseudomonas aeruginosa
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Neisseria meningitidis
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Bacillus cereus
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Proteus mirabilis
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Helicobacter pylori
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Porphyromonas gingivalis
2.7.4.1	drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Francisella tularensis
2.7.4.1	malfunction	polyphosphate kinase deletion causes decreased resistance to oxidative, heat and hyperosmotic stress, attenuated swarming and biofilm formation, increased production of prolyl isomerase, phosphotransferase and peptidoglycan synthase repressor proteins	Proteus mirabilis
2.7.4.1	malfunction	polyphosphate kinase deletion causes decreased virulence and low invasiveness	Salmonella enterica subsp. enterica serovar Typhimurium
2.7.4.1	malfunction	polyphosphate kinase deletion causes loss of biofilm formation on polyvinyl chloride (PVC) or borosilicate	Porphyromonas gingivalis
2.7.4.1	malfunction	polyphosphate kinase deletion decreases sporulation, motility and biofilm formation	Bacillus cereus
2.7.4.1	malfunction	polyphosphate kinase deletion increases sensitivity to H2O2 and reduces polyphosphate accumulation. Polyphosphate kinase deletion upregulates fermentation, aerobic and anaerobic respiration, enhances catalase and Clp protease activity, down-regulates ATP-dependent RNA helicase, DNA polymerase III and pyruvate kinase I	Escherichia coli
2.7.4.1	malfunction	polyphosphate kinase ppk1 deletion causes loss of virulence and biofilm formation, impaired motility and increased susceptibility to antibiotics. Polyphosphate kinase ppk2 deletion causes increased susceptibility to antibiotics	Pseudomonas aeruginosa
2.7.4.1	malfunction	polyphosphate kinase ppk1 deletion causes low polyphosphate accumulation, loss of virulence, reduced colonization in mice and decreased motility	Helicobacter pylori
2.7.4.1	malfunction	polyphosphate kinase ppk1 deletion causes poor survival during osmotic shock and acid challenge	Escherichia coli
2.7.4.1	malfunction	polyphosphate kinase ppk1 deletion increases serum sensitivity	Neisseria meningitidis
2.7.4.1	malfunction	polyphosphate kinase ppk2 deletion causes increased sensitivity to antibiotics	Francisella tularensis
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Salmonella enterica subsp. enterica serovar Typhimurium
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Escherichia coli
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Pseudomonas aeruginosa
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Neisseria meningitidis
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Bacillus cereus
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Proteus mirabilis
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Helicobacter pylori
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Porphyromonas gingivalis
2.7.4.1	physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Francisella tularensis