EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.53 | S-adenosyl-L-methionine | strong inhibition | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.53 | 0.021 | - |
5,10-methylenetetrahydrofolate | pH 7.2, 30°C | Sus scrofa | |
1.5.1.53 | 0.033 | - |
NADPH | pH 7.2, 30°C | Sus scrofa | |
1.5.1.53 | 0.31 | - |
NADH | pH 7.2, 30°C | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.53 | 5,10-methylenetetrahydrofolate + NADPH + H+ | Sus scrofa | - |
5-methyltetrahydrofolate + NADP+ | - |
? | |
1.5.1.53 | additional information | Sus scrofa | enzyme is specific for the (+) diastereoisomer of 5,10-methylenetetrahydrofolate as its physiological substrate. In addition, the enzyme exhibits a strong NADPH-specific diaphorase (reduced-NAD:lipoamide oxidoreductase, EC 1.8.1.4) or menadione reductase (reduced-NAD(P):(acceptor) oxidoreductase, EC 1.6.5.2 ) activity | ? | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.53 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.53 | liver | - |
Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.53 | 5,10-methylenetetrahydrofolate + NADH + H+ | NADH is a poor cofactor | Sus scrofa | 5-methyltetrahydrofolate + NAD+ | - |
? | |
1.5.1.53 | 5,10-methylenetetrahydrofolate + NADPH + H+ | - |
Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
1.5.1.53 | 5-methyltetrahydrofolate + oxidized menadione | - |
Sus scrofa | 5,10-methylenetetrahydrofolate + reduced menadione | - |
? | |
1.5.1.53 | additional information | enzyme is specific for the (+) diastereoisomer of 5,10-methylenetetrahydrofolate as its physiological substrate. In addition, the enzyme exhibits a strong NADPH-specific diaphorase (reduced-NAD:lipoamide oxidoreductase, EC 1.8.1.4) or menadione reductase (reduced-NAD(P):(acceptor) oxidoreductase, EC 1.6.5.2 ) activity | Sus scrofa | ? | - |
- |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.53 | NADH | NADPH is 10fold preferred over NADH | Sus scrofa | |
1.5.1.53 | NADPH | enzyme is specifc for NADPH | Sus scrofa |